Springer Andrea, Krüger Christin, Strube Christina, Steinhauer Dirk
Institute for Parasitology, Centre for Infection Medicine, University of Veterinary Medicine Hannover, Buenteweg 17, 30559, Hanover, Germany.
State Investigation Office Rhineland-Palatinate, Bluecherstrasse 34, 56073, Koblenz, Germany.
Curr Res Parasitol Vector Borne Dis. 2025 Aug 20;8:100309. doi: 10.1016/j.crpvbd.2025.100309. eCollection 2025.
Infections with facultatively parasitic spp. nematodes are usually fatal in animals and humans. Here, transplacental transmission of a species of is described for the first time, causing reproductive failure of a mare during two consecutive gestations. In both cases, histology showed adult and larval nematodes in the placenta and various foetal organs, without signs of generalized halicephalobosis in the mare. An identical 18S rRNA-ITS1-5.8S rRNA-ITS2 sequence generated from both placentas showed considerable divergence from a previously sequenced equine isolate, suggesting cryptic diversity among isolates in vertebrates. This ubiquitous nematode may be a cause of equine abortion associated with considerable economic loss. Future research should aim at exploring effective treatment options and clarifying the true taxonomic diversity within the genus .
兼性寄生线虫感染在动物和人类中通常是致命的。在此，首次描述了一种线虫的经胎盘传播，这种传播导致一匹母马在连续两次妊娠期间出现繁殖失败。在这两个案例中，组织学检查显示胎盘和各种胎儿器官中存在成虫和幼虫线虫，而母马没有全身性脑多头蚴病的迹象。从两个胎盘产生的相同的18S rRNA - ITS1 - 5.8S rRNA - ITS2序列与之前测序的马分离株有很大差异，这表明脊椎动物中线虫分离株存在隐性多样性。这种普遍存在的线虫可能是导致马流产的原因，会造成相当大的经济损失。未来的研究应致力于探索有效的治疗方案，并阐明该属内真正的分类多样性。
