Phaopraphat Kamonchanok, Sirijatuphat Rujipas
Division of Infectious Diseases and Tropical Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Med Mycol Case Rep. 2025 Apr 23;48:100703. doi: 10.1016/j.mmcr.2025.100703. eCollection 2025 Jun.
Cryptococcal endophthalmitis is a rare manifestation of cryptococcal infection, typically occurring in immunocompromised patients. In this case report, we present a 50-year-old female with advanced-stage lung cancer with multiple metastases presenting with blurred vision for 10 days. A diagnostic pars plana vitrectomy revealed in the vitreous. She was treated with systemic amphotericin B and flucytosine, followed by fluconazole for consolidation and maintenance, along with intravitreal amphotericin B and voriconazole injections. Her visual acuity improved from counting fingers at 2 feet to 3/60, with a pinhole correction of 6/18 after 10 months of treatment.
隐球菌性眼内炎是隐球菌感染的一种罕见表现，通常发生在免疫功能低下的患者中。在本病例报告中，我们介绍了一名50岁患有晚期肺癌并伴有多处转移的女性，她出现视力模糊10天。诊断性玻璃体切割术在玻璃体中发现了[具体内容缺失]。她接受了全身两性霉素B和氟胞嘧啶治疗，随后用氟康唑进行巩固和维持治疗，同时进行玻璃体内注射两性霉素B和伏立康唑。经过10个月的治疗，她的视力从2英尺处数手指提高到3/60，针孔矫正后为6/18。
