Stenbäck F, Wasenius V M
Photodermatol. 1985 Dec;2(6):347-58.
Basement membrane changes in human skin exposed to UV irradiation were studied by light and electron microscopy and antibodies to human collagen IV and laminin were compared to similar lesions in non-sun-exposed areas. A distinct basement membrane was seen in cases of epidermal solar keratosis, even with marked dysplasia and Bowenoid type lesions, and also around most of squamous cell carcinomas which showed basement membrane irregularities, thickening and reduplication. The invading edges of the squamous cell carcinomas with inflammatory infiltrates were devoid of laminin and collagen. Basement membrane disruption was also observed in lichen planus-type solar keratosis with severe inflammation, but with no evidence of malignancy. Alterations in basement membrane structure and location were associated with cutaneous morphological abnormalities not due to UV irradiation as such.
通过光学显微镜和电子显微镜研究了暴露于紫外线照射的人体皮肤中的基底膜变化，并将抗人IV型胶原蛋白和层粘连蛋白的抗体与未暴露于阳光区域的类似病变进行了比较。在表皮日光性角化病病例中，即使存在明显的发育异常和鲍温样型病变，也能看到明显的基底膜，在大多数显示基底膜不规则、增厚和重复的鳞状细胞癌周围也能看到。伴有炎症浸润的鳞状细胞癌的侵袭边缘缺乏层粘连蛋白和胶原蛋白。在伴有严重炎症但无恶性证据的扁平苔藓型日光性角化病中也观察到基底膜破坏。基底膜结构和位置的改变与并非由紫外线照射本身引起的皮肤形态异常有关。
