Xie Ren-Xian, Xing Yi-Xuan, Sun Nian-Zhe
Department of Orthopedics, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China.
Department of Radiation Oncology, Cancer Hospital of Shantou University Medical College, Shantou 515031, Guangdong Province, China.
World J Gastrointest Surg. 2025 Aug 27;17(8):108150. doi: 10.4240/wjgs.v17.i8.108150.
The retrospective cohort study by Zuo investigates the interplay between microsatellite instability (MSI) status, nutritional indicators, and inflammatory profiles in colorectal cancer (CRC). Analyzing 56 patients, the study reveals that MSI-high tumors are associated with significantly lower serum albumin, body mass index, and absolute lymphocyte counts, alongside elevated neutrophil-to-lymphocyte ratios compared to microsatellite stable tumors. These findings highlight distinct immunological and nutritional profiles in MSI-high CRC, suggesting potential clinical utility in risk stratification and personalized treatment. While the study underscores the importance of MSI status in CRC management, its single-center design and limited sample size warrant validation through multicenter trials. This article contextualizes these findings within the broader landscape of CRC research, emphasizing the need for integrating biomarker-driven strategies into clinical practice to optimize outcomes for patients with differing MSI statuses.
左的这项回顾性队列研究调查了微卫星不稳定性（MSI）状态、营养指标和炎症特征在结直肠癌（CRC）中的相互作用。该研究分析了56例患者，结果显示，与微卫星稳定肿瘤相比，MSI高的肿瘤与血清白蛋白、体重指数和绝对淋巴细胞计数显著降低以及中性粒细胞与淋巴细胞比率升高有关。这些发现凸显了MSI高的CRC中独特的免疫和营养特征，表明在风险分层和个性化治疗中具有潜在的临床应用价值。虽然该研究强调了MSI状态在CRC管理中的重要性，但其单中心设计和有限的样本量需要通过多中心试验进行验证。本文将这些发现置于CRC研究的更广阔背景中，强调需要将生物标志物驱动的策略纳入临床实践，以优化不同MSI状态患者的治疗结果。
