Department of Clinical Laboratory, the Third Hospital of Mianyang, Sichuan Mental Health Center, Mianyang, Sichuan, China.
Department of General Surgery, the Third Hospital of Mianyang, Sichuan Mental Health Center, Mianyang, Sichuan, China.
Crit Rev Oncol Hematol. 2024 Dec;204:104543. doi: 10.1016/j.critrevonc.2024.104543. Epub 2024 Oct 24.
The immune system plays critical roles in the initiation and progression of colorectal cancer (CRC), and the majority of studies have focused on immune perturbations within the tumor microenvironment. In recent years, systemic immunity, which mainly occurs in the periphery, has attracted much attention. In CRC, both the tumor itself and treatments have extensive effects on systemic immunity, characterized by alterations in circulating cytokines and immune cells. In addition, intact systemic immunity is critical for the efficacy of therapies for CRC, especially immunotherapy. Therefore, various strategies aimed at alleviating the detrimental effects of traditional therapies or directly harnessing the components of systemic immunity for CRC treatment have been developed. However, whether these improvements can translate to survival benefits requires further study. This review aims to comprehensively outline the current knowledge of systemic immunity in CRC.
免疫系统在结直肠癌（CRC）的发生和发展中起着关键作用，大多数研究都集中在肿瘤微环境中的免疫失调上。近年来，主要发生在外周的系统性免疫受到了广泛关注。在 CRC 中，肿瘤本身和治疗方法都会对系统性免疫产生广泛影响，表现为循环细胞因子和免疫细胞的改变。此外，完整的系统性免疫对于 CRC 治疗的疗效至关重要，特别是免疫疗法。因此，已经开发了各种旨在减轻传统疗法的有害影响或直接利用系统性免疫成分治疗 CRC 的策略。然而，这些改善是否能转化为生存获益还需要进一步研究。本综述旨在全面概述 CRC 中系统性免疫的现有知识。
