Zheng Jie, Ye Wei-Kang, Wang Jin, Zhou Yi-Nong, Yu Ting-Ting
Department of Pancreatology, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou 324000, Zhejiang Province, China.
Department of Cardiothoracic, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou 324000, Zhejiang Province, China.
World J Gastrointest Surg. 2025 Aug 27;17(8):105112. doi: 10.4240/wjgs.v17.i8.105112.
Acute pancreatitis (AP) is a potentially life-threatening complication of pancreaticoduodenectomy that increases morbidity and mortality in patients. Interleukin-17A (IL-17a) the potential preoperative marker for predicting postoperative outcomes. The purpose of this study is to retrospectively assess the prognostic value of preoperative IL-17a level in prediction of AP and related postoperative pancreatic fistula (POPF) following pancreaticoduodenectomy.
To retrospectively assess the prognostic value of preoperative IL-17a levels in predicting AP and related POPF following pancreaticoduodenectomy.
Retrospective analysis of pancreaticoduodenectomies performed on patients 150 patients between 2017 and 2023. Clinical data including pre-operative IL-17a levels were collected. The primary composite outcomes were postoperative AP and postoperative pancreatic (PP), and the predictive performances of IL-17a levels and fluid load status for postoperative complications were evaluated by statistical analysis.
A total of 150 patients were included, and 26 patients (17.3%) developed postoperative AP and 34 patients (22.7%) developed PP. Preoperative IL-17a was a risk factor for postoperative AP ( = 0.03). Furthermore, excessive intraoperative fluid load was a significantly associated ( = 0.01) with PP. The model (IL-17a levels + fluid load status) was highly accurate.
Preoperative IL-17a levels and intravascular volume status may serve as useful predictors of AP and subsequent PP following PD. These parameters provide means to evaluate preoperative risk and may guide clinical decision making to enhance postoperative recovery.
急性胰腺炎（AP）是胰十二指肠切除术一种潜在的危及生命的并发症，会增加患者的发病率和死亡率。白细胞介素-17A（IL-17a）是预测术后结局的潜在术前标志物。本研究的目的是回顾性评估术前IL-17a水平对胰十二指肠切除术后AP及相关术后胰瘘（POPF）的预测价值。
回顾性评估术前IL-17a水平对胰十二指肠切除术后AP及相关POPF的预测价值。
对2017年至2023年间150例患者进行的胰十二指肠切除术进行回顾性分析。收集包括术前IL-17a水平在内的临床资料。主要复合结局为术后AP和术后胰瘘（PP），通过统计分析评估IL-17a水平和液体负荷状态对术后并发症的预测性能。
共纳入150例患者，26例（17.3%）发生术后AP，34例（22.7%）发生PP。术前IL-17a是术后AP的危险因素（P = 0.03）。此外，术中液体负荷过多与PP显著相关（P = 0.01）。该模型（IL-17a水平+液体负荷状态）具有很高的准确性。
术前IL-17a水平和血管内容量状态可能是胰十二指肠切除术后AP及随后PP的有用预测指标。这些参数提供了评估术前风险的方法，并可能指导临床决策以促进术后恢复。
