La Quang Dai, Baloch Aiman, Ayub Muhammad, Ahmed Sobia, Jaffar Farzana, Gul Benazir, Pryor Francis, Gul Pari
Medicine, The Innovative STEMagazine 501(c)3, College Station, USA.
Biology, Texas A&M University, College Station, USA.
Cureus. 2025 Aug 14;17(8):e90073. doi: 10.7759/cureus.90073. eCollection 2025 Aug.
Aggressive angiomyxoma (AA) is a rare mesenchymal tumor that primarily occurs in women of reproductive age and arises in the pelvis and perineum (perineal area). We present the case of a 20-year-old unmarried female from Afghanistan who was sent for assessment of worsening swelling in the left vulvar and perineal regions. Imaging demonstrated a large, minimal enhancement, soft tissue mass in the left hemipelvis, which displaced organs but otherwise demonstrated no invasion. The lesion extended to the ischiorectal fossa and perineum. Owing to the clinical and radiologic findings, aggressive angiomyxoma was provisionally diagnosed, which was confirmed histologically by image-guided biopsy. The patient underwent surgical resection. Given the tumor has a known local recurrence risk, and it stained positive for estrogen and progesterone receptors, long-term follow-up and adjuvant hormonal treatment were recommended. This case highlights the importance of considering aggressive angiomyxoma in the imaging workup of vulvoperineal masses in younger women and the importance of multidisciplinary management, including imaging, to optimize patient outcomes.
侵袭性血管黏液瘤（AA）是一种罕见的间叶组织肿瘤，主要发生于育龄期女性，好发于盆腔和会阴（会阴部）。我们报告一例来自阿富汗的20岁未婚女性病例，该患者因左外阴和会阴区域肿胀加重而前来评估。影像学检查显示左半盆腔有一个较大的、强化不明显的软组织肿块，该肿块推移了周围器官，但未显示有浸润。病变延伸至坐骨直肠窝和会阴。基于临床和影像学表现，初步诊断为侵袭性血管黏液瘤，经影像引导下活检，组织学检查得以确诊。患者接受了手术切除。鉴于该肿瘤有已知的局部复发风险，且雌激素和孕激素受体染色呈阳性，建议进行长期随访和辅助激素治疗。该病例强调了在年轻女性外阴会阴肿块的影像学检查中考虑侵袭性血管黏液瘤的重要性，以及包括影像学检查在内的多学科管理对优化患者治疗效果的重要性。
