Isnaini Nadia, Muhammad Syaifullah, Prajaputra Vicky, Indra Indra, Sufriadi Elly, Ernawati Ernawati, Riski Cantika D
Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Universitas Syiah Kuala, Banda Aceh, Indonesia.
PUIPT-Nilam Aceh Atsiri Research Centre, Universitas Syiah Kuala, Banda Aceh, Indonesia.
Narra J. 2025 Aug;5(2):e1314. doi: 10.52225/narra.v5i2.1622. Epub 2025 Apr 28.
Hair issues, such as hair loss and dandruff, pose significant challenges in hair care. Patchouli oil, rich in bioactive components, has emerged as a promising candidate for addressing these concerns. The aim of this study was to investigate the hybrid functionality of fractionated patchouli oil in hair care formulations designed to promote hair growth and control dandruff caused by . Crude patchouli oil (CPO) was fractionated to enhance its efficacy, producing light fraction patchouli oil (LFPO), which was then characterized using gas chromatography-mass spectrometry (GC-MS) analysis. Hair tonic formulations containing three different LFPO concentrations (0.5%, 1.0%, and 1.5%) were developed and evaluated for stability, pH, viscosity, and antifungal activity against . The results showed that LFPO contained 2.51% acid number, 0.70% ester number, 0.71 mg/kg iron content, and 25.88% patchoulol. The formulations exhibited stable physicochemical properties, with pH levels of 5.36-5.51 and viscosity ranging from 3.94 to 4.08 centipoise (cP), suitable for hair tonic applications. Formulation of 1.5% LFPO demonstrated the strongest antifungal activity, producing a 31.18±1.37 mm inhibition zone against , surpassing ketoconazole (21.72±0.28 mm), suggesting potential as a natural antifungal agent. Histological analysis in rabbits revealed that 1.5% LFPO formulation reduced epidermal cell shedding, increased hair length by 41.6±0.35 mm after six weeks, and promoted dense hair follicle growth. This research provides a foundation for developing natural, effective, and stable hair care formulations. Despite these promising results, the efficacy and safety of LFPO formulations in humans remain unexplored. Therefore, a clinical human trial is necessary to assess skin tolerance, irritation risks, and long-term effects under real-world conditions.
脱发和头皮屑等头发问题在头发护理中构成了重大挑战。富含生物活性成分的广藿香精油已成为解决这些问题的有潜力的候选物。本研究的目的是研究分馏广藿香精油在旨在促进头发生长和控制由……引起的头皮屑的头发护理配方中的混合功能。对粗制广藿香精油（CPO）进行分馏以提高其功效，制得轻质分馏广藿香精油（LFPO），然后使用气相色谱-质谱联用（GC-MS）分析对其进行表征。开发了含有三种不同LFPO浓度（0.5%、1.0%和1.5%）的生发剂配方，并对其稳定性、pH值、粘度以及针对……的抗真菌活性进行了评估。结果表明，LFPO的酸值为2.51%，酯值为0.70%，铁含量为0.71 mg/kg，广藿香醇含量为25.88%。这些配方表现出稳定的物理化学性质，pH值在5.36 - 5.51之间，粘度在3.94至4.08厘泊（cP）之间，适用于生发剂应用。1.5% LFPO配方表现出最强的抗真菌活性，对……产生了31.18±1.37毫米的抑菌圈，超过了酮康唑（21.72±0.28毫米），表明其作为天然抗真菌剂的潜力。对兔子的组织学分析表明，1.5% LFPO配方减少了表皮细胞脱落，六周后头发长度增加了41.6±0.35毫米，并促进了密集的毛囊生长。这项研究为开发天然、有效和稳定的头发护理配方奠定了基础。尽管有这些令人鼓舞的结果，但LFPO配方在人体中的功效和安全性仍未得到探索。因此，有必要进行一项临床人体试验，以评估在实际条件下的皮肤耐受性、刺激风险和长期影响。
