Komchornrit Aurasri, Sodata Patteera, Theerautthavate Benyada, Techatanawat Suteera
Department of General Dentistry, Faculty of Dentistry, Srinakharinwirot University, Wattana, Bangkok, Thailand.
Division of Pharmaceutical Sciences, Faculty of Pharmacy, Thammasat University, Pathum Thani, Thailand.
J Int Soc Prev Community Dent. 2025 Jul 29;15(4):340-347. doi: 10.4103/jispcd.jispcd_77_25. eCollection 2025 Jul-Aug.
To investigate the antimicrobial efficacy of an aloe vera (ALOE)-based mouthwash against key cariogenic pathogens in adults with dental caries, comparing its effects to a standard chlorhexidine (CHX) mouthwash.
In this single-blind, randomized clinical trial, 54 adults with active dental caries (decayed, missing, and filled teeth [DMFT] ≥3) were assigned to either an ALOE ( = 27) or a 0.12% CHX ( = 27) mouthwash group for a 7-day regimen. Unstimulated saliva was collected at baseline and post-intervention. Salivary levels of , , and were semi-quantitatively assessed using a modified dip-slide test. Statistical analyses, including the Wilcoxon signed-rank and Mann-Whitney -tests, were performed with significance set at < 0.05.
Post-intervention, the ALOE group demonstrated a significant reduction in salivary levels ( = 0.008). While a decrease in was observed, it was not statistically significant ( = 0.096). The CHX group showed significant reductions in both ( = 0.046) and ( = 0.002). Neither group exhibited a significant change in levels, nor significant differences in microbial counts were found between the two groups after the 7-day period.
ALOE mouthwash demonstrates significant antifungal activity against salivary in adults with dental caries, positioning it as a potential natural alternative for managing oral fungal loads. While its effect on was not as pronounced as CHX in this short-term trial, its efficacy against warrants further investigation into its long-term benefits for oral health maintenance.
研究一种基于芦荟（ALOE）的漱口水对患有龋齿的成年人主要致龋病原体的抗菌效果，并将其与标准的氯己定（CHX）漱口水的效果进行比较。
在这项单盲、随机临床试验中，54名患有活动性龋齿（龋失补牙数[DMFT]≥3）的成年人被分配到芦荟漱口水组（n = 27）或0.12%氯己定漱口水组（n = 27），进行为期7天的疗程。在基线和干预后收集非刺激性唾液。使用改良的浸片试验对唾液中变形链球菌、远缘链球菌和白色念珠菌的水平进行半定量评估。进行了包括Wilcoxon符号秩检验和Mann-Whitney U检验在内的统计分析，显著性设定为P < 0.05。
干预后，芦荟漱口水组唾液中变形链球菌水平显著降低（P = 0.008）。虽然观察到远缘链球菌有所减少，但无统计学意义（P = 0.096）。氯己定漱口水组的变形链球菌（P = 0.046）和远缘链球菌（P = 0.002）均显著减少。两组白色念珠菌水平均无显著变化，7天疗程后两组微生物计数也无显著差异。
芦荟漱口水对患有龋齿的成年人唾液中的变形链球菌具有显著的抗真菌活性，使其成为管理口腔真菌负荷的潜在天然替代品。虽然在这项短期试验中其对远缘链球菌的效果不如氯己定明显，但其对变形链球菌的疗效值得进一步研究其对口腔健康维持的长期益处。
