Du Qian, Ren Biao, Zhou Xuedong, Zhang Ling, Xu Xin
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Front Microbiol. 2022 Nov 3;13:911623. doi: 10.3389/fmicb.2022.911623. eCollection 2022.
is a symbiotic fungus that commonly colonizes on oral mucosal surfaces and mainly affects immuno-compromised individuals. Polymicrobial interactions between and oral microbes influence the cellular and biochemical composition of the biofilm, contributing to change clinically relevant outcomes of biofilm-related oral diseases, such as pathogenesis, virulence, and drug-resistance. Notably, the symbiotic relationships between and oral bacteria have been well-documented in dental caries, oral mucositis, endodontic and periodontal diseases, implant-related infections, and oral cancer. interacts with co-existing oral bacteria through physical attachment, extracellular signals, and metabolic cross-feeding. This review discusses the bacterial-fungal interactions between and different oral bacteria, with a particular focus on the underlying mechanism and its relevance to the development and clinical management of oral diseases.
是一种共生真菌，通常定殖于口腔黏膜表面，主要影响免疫功能低下的个体。[该真菌名称缺失]与口腔微生物之间的多微生物相互作用会影响生物膜的细胞和生化组成，从而导致生物膜相关口腔疾病的临床相关结果发生变化，如发病机制、毒力和耐药性。值得注意的是，[该真菌名称缺失]与口腔细菌之间的共生关系在龋齿、口腔黏膜炎、牙髓病和牙周病、种植体相关感染以及口腔癌中已有充分记载。[该真菌名称缺失]通过物理附着、细胞外信号和代谢互养与共存的口腔细菌相互作用。本综述讨论了[该真菌名称缺失]与不同口腔细菌之间的细菌-真菌相互作用，特别关注其潜在机制及其与口腔疾病发生发展和临床管理的相关性。
