中国心血管-肾脏-代谢综合征0-3期中老年人群中甘油三酯葡萄糖-腰高比指数与心血管疾病之间的非线性关联
The nonlinear association between the triglyceride glucose-waist-to-height ratio index and cardiovascular disease among middle-aged and older adults in China with cardiovascular-kidney-metabolic syndrome stages 0-3.
作者信息
Huang Cheng, Jia Jing, He Yuanyuan
机构信息
Department of Colorectal Surgery, First People's Hospital of Xiaoshan District, Hangzhou, Zhejiang, China.
Department of Emergency, First People's Hospital of Xiaoshan District, Hangzhou, Zhejiang, China.
出版信息
Front Cardiovasc Med. 2025 Aug 29;12:1604270. doi: 10.3389/fcvm.2025.1604270. eCollection 2025.
BACKGROUND
Cardiovascular disease (CVD) poses a critical challenge to global public health, especially in individuals with Cardiovascular-Kidney-Metabolic (CKM) syndrome. The association between the triglyceride glucose-waist-to-height ratio index (TyG-WHtR) and CVD among middle-aged and older Chinese adults with CKM stages 0-3 is not well understood.
METHODS
Data were obtained from the China Health and Retirement Longitudinal Study (CHARLS), a nationally representative longitudinal study of individuals aged 45 years and older. Cox proportional hazards models were constructed to evaluate the association between TyG-WHtR and CVD risk. Subgroup analyses were conducted among different groups to evaluate consistency of findings and explore potential interactions. Restricted cubic spline regression was employed to evaluate the dose-response relationship.
RESULTS
During a mean follow-up period of 7.77 ± 2.13 years, 1,595 participants (23.58%) developed CVD. After adjusting for covariates, TyG-WHtR was significantly associated with CVD risk (HR: 1.09, 95% CI: 1.01-1.18). Notably, this relationship was independent of other variables and displayed a nonlinear pattern, with an inflection point identified at 3.57. Beyond this threshold, the adjusted HR increased to 1.17 (95%CI: 1.08-1.71).
CONCLUSION
TyG-WHtR demonstrates a nonlinear relationship with CVD among middle-aged and older Chinese adults with CKM stages 0-3.
背景
心血管疾病（CVD）对全球公共卫生构成了严峻挑战，尤其是在患有心血管-肾脏-代谢（CKM）综合征的个体中。甘油三酯葡萄糖-腰高比指数（TyG-WHtR）与0-3期CKM的中国中老年成年人的CVD之间的关联尚不清楚。
方法
数据来自中国健康与养老追踪调查（CHARLS），这是一项对45岁及以上个体具有全国代表性的纵向研究。构建Cox比例风险模型以评估TyG-WHtR与CVD风险之间的关联。在不同组中进行亚组分析以评估结果的一致性并探索潜在的相互作用。采用受限立方样条回归评估剂量反应关系。
结果
在平均7.77±2.13年的随访期内，1595名参与者（23.58%）发生了CVD。在调整协变量后，TyG-WHtR与CVD风险显著相关（HR：1.09，95%CI：1.01-1.18）。值得注意的是，这种关系独立于其他变量，并呈现出非线性模式，在3.57处确定了一个拐点。超过这个阈值，调整后的HR增加到1.17（95%CI：1.08-1.71）。
结论
在0-3期CKM的中国中老年成年人中，TyG-WHtR与CVD呈非线性关系。
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