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美国产后阿片类药物的使用及其对孕产妇和公共卫生的影响:一项范围综述

Postpartum Opioid Use in the United States and the Implications to Maternal and Public Health: A Scoping Review.

作者信息

Miller Allison N, Daniels Dennis E N, Heavey Sarah Cercone

机构信息

Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, State University of New York at Buffalo, Buffalo, NY, 14214, USA.

Department of Community Health & Health Behavior, School of Public Health & Health Professions, State University of New York at Buffalo, Buffalo, NY, 14214, USA.

出版信息

Matern Child Health J. 2025 Sep 15. doi: 10.1007/s10995-025-04163-x.

DOI:10.1007/s10995-025-04163-x
PMID:40952655
Abstract

INTRODUCTION/PURPOSE: Postpartum opioid prescription rates remain high, leading to increased morbidity and mortality and increased licit opioid medications diverted into communities. This scoping analysis examined the current processes of postpartum opioid prescribing patterns in America and the implications to maternal and public health.

METHODS

From the databases PubMed, Medline, and Web of Science, a scoping review was performed utilizing the PRISMA-ScR checklist (Tricco et al. in Ann Intern Med 169(7):467-473, 2018, https://doi.org/10.7326/M18-0850 ). The primary objective of the search strategy was to identify studies that focused on the postpartum timeframe (obstetric delivery to one year postpartum) and prescribed opioids.

RESULTS

A total of 26 articles met inclusion criteria. Articles were broken down into four themes: trends or current state of postpartum opioid prescribing practices (n = 7); postpartum opioid related risk factors (n = 6); rates of new persistent opioid use and opioid use disorder (OUD; n = 5); protocols or research into reducing postpartum opioid use (n = 8).

DISCUSSION/CONCLUSION: A variety of interventions and protocols have been found to be advantageous in reducing postpartum opioid use. Despite many of these successful efforts, postpartum opioid prescription rates remain high. Implementation of any number of interventions and protocols may be beneficial to reducing postpartum opioid use. Initiating a postpartum pain task force protocol (PPTFP) before obstetric delivery is recommended.

摘要

引言/目的:产后阿片类药物的处方率仍然很高,导致发病率和死亡率上升,以及更多合法阿片类药物流入社区。本范围分析研究了美国目前产后阿片类药物处方模式的过程及其对孕产妇和公共卫生的影响。

方法

利用PRISMA-ScR清单(Tricco等人,《内科学年鉴》169(7):467-473,2018年,https://doi.org/10.7326/M18-0850),在PubMed、Medline和科学网数据库中进行了范围综述。检索策略的主要目标是识别关注产后时间段(从产科分娩到产后一年)并开具阿片类药物的研究。

结果

共有26篇文章符合纳入标准。文章分为四个主题:产后阿片类药物处方实践的趋势或现状(n = 7);产后阿片类药物相关风险因素(n = 6);新的持续阿片类药物使用和阿片类药物使用障碍(OUD)的发生率(n = 5);减少产后阿片类药物使用的方案或研究(n = 8)。

讨论/结论:已发现多种干预措施和方案在减少产后阿片类药物使用方面具有优势。尽管有许多这些成功的努力,但产后阿片类药物处方率仍然很高。实施任何数量的干预措施和方案可能有助于减少产后阿片类药物的使用。建议在产科分娩前启动产后疼痛特别工作组方案(PPTFP)。

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Postpartum Opioid Use in the United States and the Implications to Maternal and Public Health: A Scoping Review.美国产后阿片类药物的使用及其对孕产妇和公共卫生的影响:一项范围综述
Matern Child Health J. 2025 Sep 15. doi: 10.1007/s10995-025-04163-x.
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本文引用的文献

1
Variations in Postpartum Opioid Prescribing Practices among Obstetrician-Gynecologists.妇产科医生产后阿片类药物处方行为的差异
Kans J Med. 2022 Oct 24;15(3):373-379. doi: 10.17161/kjm.vol15.18246. eCollection 2022.
2
Risk of Death at 1 Year Following Postpartum Opioid Exposure.产后接触阿片类药物 1 年后的死亡风险。
Am J Perinatol. 2024 May;41(7):949-960. doi: 10.1055/s-0042-1745848. Epub 2022 May 31.
3
Association Between Patient-Prescriber Racial and Ethnic Concordance and Postpartum Pain and Opioid Prescribing.
患者与开处方者的种族和民族一致性与产后疼痛及阿片类药物处方之间的关联
Health Equity. 2022 Mar 7;6(1):198-205. doi: 10.1089/heq.2021.0130. eCollection 2022.
4
Predictors of patient post-discharge opioid use after cesarean delivery: a prospective study.剖宫产术后患者出院后使用阿片类药物的预测因素:一项前瞻性研究。
Int J Obstet Anesth. 2022 May;50:103249. doi: 10.1016/j.ijoa.2021.103249. Epub 2021 Dec 30.
5
The impact of race on postpartum opioid prescribing practices: a retrospective cohort study.种族对产后阿片类药物处方实践的影响:一项回顾性队列研究。
BMC Pregnancy Childbirth. 2021 Jun 22;21(1):434. doi: 10.1186/s12884-021-03954-8.
6
Prescription Opioid Dose After Vaginal Delivery and the Risk of Serious Opioid-Related Events: A Retrospective Cohort Study.阴道分娩后开具的处方类阿片类药物剂量与严重阿片类药物相关不良事件风险:一项回顾性队列研究。
Womens Health Issues. 2021 Jul-Aug;31(4):376-383. doi: 10.1016/j.whi.2021.03.002. Epub 2021 Apr 15.
7
The PRISMA 2020 statement: an updated guideline for reporting systematic reviews.PRISMA 2020 声明:系统评价报告的更新指南。
BMJ. 2021 Mar 29;372:n71. doi: 10.1136/bmj.n71.
8
Implementation of a Standardized Post-Cesarean Delivery Order Set with Multimodal Combination Analgesia Reduces Inpatient Opioid Usage.实施包含多模式联合镇痛的标准化剖宫产术后医嘱集可减少住院期间阿片类药物的使用。
J Clin Med. 2020 Dec 22;10(1):7. doi: 10.3390/jcm10010007.
9
Decreasing Opioid Use Postpartum: A Quality Improvement Initiative.产后减少阿片类药物使用:一项质量改进倡议。
Obstet Gynecol. 2019 Nov;134(5):932-940. doi: 10.1097/AOG.0000000000003512.
10
Rates of New Persistent Opioid Use After Vaginal or Cesarean Birth Among US Women.美国女性阴道分娩或剖宫产术后新发持续性阿片类药物使用的发生率。
JAMA Netw Open. 2019 Jul 3;2(7):e197863. doi: 10.1001/jamanetworkopen.2019.7863.