Lutski Miri, Karni-Efrati Ziv, Zucker Inbar, Frankenthal Dvora
The Israel Center for Disease Control (ICDC), Ministry of Health, Sheba Medical Center, Ramat Gan, Israel.
School of Public Health, Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.
Eur Geriatr Med. 2025 Sep 15. doi: 10.1007/s41999-025-01297-7.
With aging population and the growing burden of sarcopenia on health systems, early risk assessment is essential. This study assessed the risk of sarcopenia and associated factors among community-dwelling older adults.
This cross-sectional study used data from the Israel National Elderly Falls Survey (2018-2019) among adults aged 65+ by the Israel Center for Disease Control. Data were collected via telephone interviews on demographic, health, and functional characteristics. Sarcopenia risk was assessed using the validated five-item Mini Sarcopenia Risk Assessment (MSRA-5) questionnaire, with a cutoff score of ≤ 45 indicating risk. Multivariable logistic regression estimated odds ratios (ORs) and 95% confidence intervals (CIs) for sarcopenia risk.
A total of 2668 participants were included in the study, with a mean age of 73.2 ± 5.7 years, and 56.3% were female. Based on the MSRA-5 cutoff score (≤ 45), 65.1% (n = 1738) were classified as at risk for sarcopenia. Older age (OR = 1.21 per 5-year increase, 95% CI 1.10-1.33), Arab ethnicity (OR = 2.05, 95% CI 1.59-2.64), lower education level (OR = 1.57, 95% CI 1.29-1.92), and anxiety/depression (OR = 1.83, 95% CI 1.32-2.54) were associated with the prevalence of sarcopenia risk. Functional limitations, including difficulty performing household activities (OR = 1.96, 95% CI 1.42-2.69) and physical inactivity (OR = 1.72, 95% CI 1.40-2.11), were also associated with sarcopenia risk. A dose-response relationship was observed with medication use, with progressively higher odds of sarcopenia risk among those taking > 8 medications per day (OR = 2.75, 95% CI 1.52-4.98).
These findings highlight the high prevalence of sarcopenia risk among older adults in Israel and emphasize the importance of early screening to identify at-risk individuals.
随着人口老龄化以及肌肉减少症给卫生系统带来的负担日益加重，早期风险评估至关重要。本研究评估了社区居住的老年人中肌肉减少症的风险及相关因素。
这项横断面研究使用了以色列疾病控制中心对65岁及以上成年人进行的以色列全国老年人跌倒调查（2018 - 2019年）的数据。通过电话访谈收集了关于人口统计学、健康和功能特征的数据。使用经过验证的五项简易肌肉减少症风险评估（MSRA - 5）问卷评估肌肉减少症风险，临界值分数≤45分表明存在风险。多变量逻辑回归估计了肌肉减少症风险的比值比（OR）和95%置信区间（CI）。
共有2668名参与者纳入研究，平均年龄为73.2±5.7岁，56.3%为女性。根据MSRA - 5临界值分数（≤45），65.1%（n = 1738）被归类为有肌肉减少症风险。年龄较大（每增加5岁OR = 1.21，95% CI 1.10 - 1.33）、阿拉伯族裔（OR = 2.05，95% CI 1.59 - 2.64）、教育水平较低（OR = 1.57，95% CI 1.29 - 1.92）以及焦虑/抑郁（OR = 1.83，95% CI 1.32 - 2.54）与肌肉减少症风险的患病率相关。功能受限，包括进行家务活动困难（OR = 1.96，95% CI 1.42 - 2.69）和身体活动不足（OR = 1.72，95% CI 1.40 - 2.11）也与肌肉减少症风险相关。在药物使用方面观察到剂量反应关系，每天服用超过8种药物的人群中肌肉减少症风险的比值比逐渐升高（OR = 2.75，95% CI 1.52 - 4.98）。
这些发现凸显了以色列老年人中肌肉减少症风险的高患病率，并强调了早期筛查以识别高危个体的重要性。
