Dagsuyu Eda, Kies Paige, Patel Robin, Beyenal Haluk
School of Chemical Engineering and Bioengineering, Voiland College of Engineering and Architecture, Washington State University, Pullman, Washington, USA.
Department of Chemistry, Faculty of Engineering, Istanbul University-Cerrahpaşa, Istanbul, Turkey.
Wound Repair Regen. 2025 Sep-Oct;33(5):e70092. doi: 10.1111/wrr.70092.
An electrochemical bandage (e-bandage) that generates hydrogen peroxide (HO) through a combination of working, counter and reference electrodes used with an electrolyte-providing hydrogel is being developed for wound infection management. e-Bandage biocidal activity was previously demonstrated using Xanthan gum hydrogel. For clinical use, clinically used hydrogels would be ideal, but their use with the described e-bandage has not been shown. The goal of this work was to evaluate the biocidal activity of off-the-shelf, clinically used hydrogels when used with a 1.77 cm HO-producing e-bandage. e-Bandage electrochemical parameters and activity against methicillin-resistant Staphylococcus aureus IDRL-6169 and Acinetobacter baumannii ATCC-17978 biofilms were assessed with six off-the-shelf hydrogels. Variations in hydrogel composition affected electrochemical parameters, which was associated with differences in biocidal activity. Results of this study inform the selection of off-the-shelf hydrogels for use with HO-producing e-bandages.
一种通过工作电极、对电极和参比电极与提供电解质的水凝胶结合来产生过氧化氢（HO）的电化学绷带（电子绷带）正在被研发用于伤口感染管理。电子绷带的杀菌活性先前已使用黄原胶水凝胶得到证明。对于临床应用而言，临床使用的水凝胶会是理想之选，但尚未证明其与所述电子绷带的联用效果。这项工作的目标是评估市售的临床使用水凝胶与产生1.77厘米HO的电子绷带联用时的杀菌活性。使用六种市售水凝胶评估了电子绷带的电化学参数以及对耐甲氧西林金黄色葡萄球菌IDRL - 6169和鲍曼不动杆菌ATCC - 17978生物膜的活性。水凝胶成分的变化影响了电化学参数，这与杀菌活性的差异相关。本研究结果为选择与产生HO的电子绷带联用的市售水凝胶提供了依据。
