Feng Jun-Yan, Bai Miao-Shui, Dong Han-Yu, Xue Yang, Liu Yu-Mo, Ma Huan, Mohamed Zakaria Ahmed, Shan Ling, Jia Fei-Yong
Department of Developmental and Behavioral Pediatrics, Children's Medical Center, The First Hospital of Jilin University, Changchun, China.
The Child Health Clinical Research Center of Jilin Province, Changchun, China.
Pediatr Res. 2025 Sep 16. doi: 10.1038/s41390-025-04375-5.
We investigated the effectiveness of individual-Early Start Denver Model (I-ESDM) and group-ESDM (G-ESDM) intervention in children with autism spectrum disorder (ASD) at varying ability levels.
A total of 404 children were divided into I-ESDM (n = 237) and G-ESDM (n = 167) groups, receiving 3-month of intervention. The I-ESDM group had a staff-to-child ratio of 1:1, while the G-ESDM group had a ratio of 2:6. Clinical symptoms, neurodevelopment, and parenting stress were evaluated both pre- and post-treatment.
After 3 months, both interventions significantly improved clinical symptoms, neurodevelopment, and reduced parenting stress in children with ASD. In the language age group under 2 years, the I-ESDM subgroup showed greater improvements in clinical symptoms compared to the G-ESDM subgroup. In the ≥2-year language age group and the general quotient (GQ) ≥ 70 group, the G-ESDM subgroup demonstrated greater improvements in clinical symptoms and neurodevelopment compared to the I-ESDM subgroup.
Both I-ESDM and G-ESDM effectively improve clinical symptoms, neurodevelopment, and reduce parenting stress in children with ASD. I-ESDM was more effective for children with a language age <2 years, while G-ESDM showed better outcomes for those with a language age ≥2 years or GQ ≥ 70.
After 3 months, both individual-Early Start Denver Model (I-ESDM) and group-ESDM (G-ESDM) significantly improved clinical symptoms, neurodevelopment, and reduced parenting stress in children with ASD. The I-ESDM subgroup showed greater improvements in clinical symptoms in children under 2 years of age. The G-ESDM subgroup demonstrated superior improvements in clinical symptoms and neurodevelopment in children aged ≥2 years or those with GQ ≥ 70.
我们调查了个体早期丹佛模式（I-ESDM）和小组早期丹佛模式（G-ESDM）干预对不同能力水平的自闭症谱系障碍（ASD）儿童的有效性。
总共404名儿童被分为I-ESDM组（n = 237）和G-ESDM组（n = 167），接受为期3个月的干预。I-ESDM组的师生比为1:1，而G-ESDM组的师生比为2:6。在治疗前后评估临床症状、神经发育和育儿压力。
3个月后，两种干预措施均显著改善了ASD儿童的临床症状、神经发育，并减轻了育儿压力。在2岁以下的语言年龄组中，I-ESDM亚组在临床症状方面的改善比G-ESDM亚组更大。在语言年龄≥2岁且总智商（GQ）≥70的组中，G-ESDM亚组在临床症状和神经发育方面的改善比I-ESDM亚组更大。
I-ESDM和G-ESDM均能有效改善ASD儿童的临床症状、神经发育，并减轻育儿压力。I-ESDM对语言年龄<2岁的儿童更有效，而G-ESDM对语言年龄≥2岁或GQ≥70的儿童效果更好。
3个月后，个体早期丹佛模式（I-ESDM）和小组早期丹佛模式（G-ESDM）均显著改善了ASD儿童 的临床症状、神经发育，并减轻了育儿压力。I-ESDM亚组在2岁以下儿童的临床症状方面有更大改善。G-ESDM亚组在≥2岁儿童或GQ≥70的儿童的临床症状和神经发育方面表现出更好的改善。
