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黏弹剂环形缝合小梁切开粘连松解联合超声乳化术与单纯超声乳化术治疗慢性原发性闭角型青光眼的比较

Visco-circumferential-suture-trabeculotomy-synechiolysis with phacoemulsification versus phacoemulsification alone for chronic primary angle closure glaucoma.

作者信息

Elwehidy Ahmed S, Abdelkader Amr Mohammed Elsayed, Hagras Sherein M, GabAllah Nada M, Elwehidy Mostafa As, Abdelfattah Dina

机构信息

Department of Ophthalmology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.

Department of Ophthalmology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.

出版信息

BMC Ophthalmol. 2025 Sep 16;25(1):503. doi: 10.1186/s12886-025-04373-5.

Abstract

PURPOSE

To assess the surgical outcomes of visco-circumferential-suture-trabeculotomy-synechiolysis (VCSTS) with phacoemulsification compared with phacoemulsification alone for the treatment of chronic primary angle closure glaucoma (PACG).

SETTINGS

Mansoura Ophthalmic Center, Mansoura, Egypt.

DESIGN

Retrospective double armed interventional non randomized comparative study.

METHODS

A total of 88 eyes (69 patients) with uncontrolled PACG between 2016 and 2022 were subjected to VCSTS with phacoemulsification (Group 1) or phacoemulsification (PE) alone (Group 2). The follow-up period was 24 months. Success was defined as an IOP between 6 and 18 mmHg, with a reduction of at least 30% from baseline with (qualified) or without (complete) antiglaucoma medications (AGMs).

RESULTS

The mean ± standard deviation ages of the study patients in groups 1 and 2 were 61.1±0.9 and 61.7±0.8 years (p=0.536), respectively. The means ± standard deviations of the preoperative and final postoperative IOP and AGM in groups 1 and 2 were 27.46±0.32 and 28.0±0.3 and 14.15±1.1 and 16.7±0.71 mmHg, respectively (p<0.001), and 3.18±0.07 and 3.2±0.9 and 0.47±1.1 and 1.1±1.5, respectively (p=0.035). The rates of complete success (Kaplan‒Meier) in groups 1 and 2 were 95.3% and 86.7%, respectively (p=0.153). Mild self-limited hyphema was the most common complication in Group 1, with no serious complications reported in Group 2.

CONCLUSIONS

Phacoemulsification results in a significant and sustained reduction in IOP and the need for AGMs for at least 2 years of follow-up. The addition of VCSTS to phacoemulsification provides a greater reduction in IOP and AGMs and improved surgical success without serious complications.

摘要

目的

评估与单纯白内障超声乳化术相比,超声乳化联合粘弹剂环形缝扎小梁切开及粘连松解术(VCSTS)治疗慢性原发性闭角型青光眼(PACG)的手术效果。

地点

埃及曼苏拉曼苏拉眼科中心。

设计

回顾性双臂干预非随机对照研究。

方法

2016年至2022年间,共有88只眼(69例患者)患有未控制的PACG,接受了超声乳化联合VCSTS(第1组)或单纯超声乳化术(PE,第2组)。随访期为24个月。成功定义为眼压在6至18 mmHg之间,使用(合格)或不使用(完全)抗青光眼药物(AGM)时眼压较基线降低至少30%。

结果

第1组和第2组研究患者的平均±标准差年龄分别为61.1±0.9岁和61.7±0.8岁(p = 0.536)。第1组和第2组术前和术后最终眼压及AGM的平均值±标准差分别为27.46±0.32和28.0±0.3以及14.15±1.1和16.7±0.71 mmHg(p < 0.001),以及3.18±0.07和3.2±0.9以及0.47±1.1和1.1±1.5(p = 0.035)。第1组和第2组的完全成功率(Kaplan-Meier)分别为95.3%和86.7%(p = 0.153)。轻度自限性前房积血是第1组最常见的并发症,第2组未报告严重并发症。

结论

白内障超声乳化术可使眼压显著且持续降低,并且在至少2年的随访期内减少了对抗青光眼药物的需求。在白内障超声乳化术中加用VCSTS可使眼压和抗青光眼药物使用量进一步降低,并提高手术成功率,且无严重并发症。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0629/12439390/8faee267cc1d/12886_2025_4373_Fig1_HTML.jpg

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