Otsuki Koji, Shuhama Rui, Wake Rei, Inagaki Masatoshi
Department of Psychiatry, Faculty of Medicine, Shimane University, Izumo, Japan.
Dai-ichi Life Research Institute Inc., Tokyo, Japan.
Medicine (Baltimore). 2025 Sep 12;104(37):e44547. doi: 10.1097/MD.0000000000044547.
The current study sought to clarify the relationship between the self-administered Brief Job Stress Questionnaire (BJSQ) and urinary biopyrrin levels, which are elevated in response to stress. A cross-sectional study was conducted with employees of companies in Kanagawa, Japan. Participants were asked to complete the BJSQ and ad hoc questionnaires, and urinary biopyrrin levels were measured. We investigated the correlations between psychological and physical stress response scores on the BJSQ and urinary biopyrrin levels. Correlations between subscale scores of the BJSQ and urinary biopyrrin levels were then examined. Additionally, differences in urinary biopyrrin levels were examined using ad hoc questionnaires. In total, 105 subjects participated in this study. No correlations were found between stress response scores and urinary biopyrrin levels. For the 2 subscales of the BJSQ (suitable jobs and meaningfulness of work), the higher the score, the higher the urinary biopyrrin levels. Analysis of ad hoc questionnaire results revealed that urinary biopyrrin levels were significantly higher in individuals who requested regular stress checks by urine testing, compared with those that did not. The results suggested that urinary biopyrrin levels may be an indicator of individuals' overadjustment to the work environment. A follow-up study will be necessary to investigate the development of psychiatric disorders in individuals with high urinary biopyrrin levels.
本研究旨在阐明自行填写的简易工作压力问卷（BJSQ）与因压力而升高的尿双吡咯水平之间的关系。对日本神奈川县各公司的员工进行了一项横断面研究。参与者被要求完成BJSQ和特别问卷，并测量尿双吡咯水平。我们调查了BJSQ上心理和生理压力反应得分与尿双吡咯水平之间的相关性。然后检查了BJSQ各子量表得分与尿双吡咯水平之间的相关性。此外，使用特别问卷检查了尿双吡咯水平的差异。共有105名受试者参与了本研究。压力反应得分与尿双吡咯水平之间未发现相关性。对于BJSQ的两个子量表（合适的工作和工作意义），得分越高，尿双吡咯水平越高。对特别问卷结果的分析显示，与未要求通过尿液检测进行定期压力检查的个体相比，要求通过尿液检测进行定期压力检查的个体尿双吡咯水平显著更高。结果表明，尿双吡咯水平可能是个体对工作环境过度适应的一个指标。有必要进行一项后续研究，以调查尿双吡咯水平高的个体中精神障碍的发展情况。
