Bashir Bashir Abdrhman, Mohamed Hagar M, Hassan Mohamed M, Ali Walaa Yasier, Moglad Ehssan, Hussain Mohamed A, Osman Wadah, Alsiyud Duaa Fahad, Mohamed Gamal A, Ibrahim Sabrin R M
Department of Hematology, Faculty of Medical Laboratory Sciences, Port Sudan Ahlia University, Port Sudan 33312, Sudan.
Department of Medical Laboratory Analysis, College of Medical & Health Sciences, Liwa University, Abu Dhabi 41009, UAE.
Interdiscip Perspect Infect Dis. 2025 Sep 8;2025:2583917. doi: 10.1155/ipid/2583917. eCollection 2025.
Iron indices are pivotal in tuberculosis (TB) owing to their influence on pathogens and immune reactions. Iron indices substantially affect TB progression, resulting in inflammation and anemia. Tuberculosis can induce iron deficiency or excess that may result in compromised immunological function. This study examined the iron index hemoglobin (Hb), serum iron, ferritin, total iron binding capacity (TIBC), unsaturated iron binding capacity (UIBC), and transferrin saturation (TSAT) in PTB patients. Between January 2016 and December 2018, the Port Sudan Tuberculosis Diagnostic Center studied a cohort of 100 adult patients definitively diagnosed with PTB. Additionally, 100 healthy individuals of similar age and sex were chosen as controls for comparative analysis. Among the 100 PTB patients studied, 90% (90/100) had anemia, with an odds ratio of 0.923 (95% CI 0.82-1.04). Anemia of chronic disease (ACD) was the most prevalent type (37%, 31/90). The patients showed diminished levels of HB, serum iron, TIBC, and TSAT compared to the controls, except for ferritin levels. UIBC was higher in patients than in controls, but this difference was not statistically significant. The research concludes that iron metabolism is modified during tuberculosis infection. Consequently, anemia in PTB patients is primarily attributed to ACD rather than iron shortage. The indices of serum iron, TIBC, and UIBC were ineffective in distinguishing between the forms of anemia in PTB patients, as their levels fluctuated in response to the infection. Ferritin served as superior metric for distinguishing between anemia of chronic disease and iron deficiency anemia.
由于铁指标对病原体和免疫反应有影响，所以在结核病（TB）中至关重要。铁指标会极大地影响结核病的进展，从而导致炎症和贫血。结核病可诱发铁缺乏或铁过量，这可能会导致免疫功能受损。本研究检测了肺结核（PTB）患者的铁指标血红蛋白（Hb）、血清铁、铁蛋白、总铁结合力（TIBC）、不饱和铁结合力（UIBC）和转铁蛋白饱和度（TSAT）。2016年1月至2018年12月期间，苏丹港结核病诊断中心对一组100例确诊为PTB的成年患者进行了研究。此外，还选取了100名年龄和性别相仿的健康个体作为对照进行比较分析。在研究的100例PTB患者中，90%（90/100）患有贫血，比值比为0.923（95%可信区间0.82 - 1.04）。慢性病贫血（ACD）是最常见的类型（37%，31/90）。与对照组相比，患者的Hb、血清铁、TIBC和TSAT水平降低，但铁蛋白水平除外。患者的UIBC高于对照组，但这种差异无统计学意义。研究得出结论，结核病感染期间铁代谢会发生改变。因此，PTB患者的贫血主要归因于ACD而非铁缺乏。血清铁、TIBC和UIBC指标在区分PTB患者贫血类型方面无效，因为它们的水平会随感染而波动。铁蛋白是区分慢性病贫血和缺铁性贫血的更优指标。
