Weng Wei-Chun, Lin Tien-Huang, He Xiu-Yuan, Lin Chia-Yen, Wu Hsi-Chin, Huang Yuan-Li, Lai Chao-Yang, Tsai Chun-Hao, Fong Yi-Chin, Yang Shun-Fa, Tang Chih-Hsin
Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan.
Division of Urology, Department of Surgery, Tungs' Taichung Metroharbor Hospital, Taichung, Taiwan.
J Cancer. 2025 Aug 11;16(12):3767-3774. doi: 10.7150/jca.119089. eCollection 2025.
One of the most prevalent cancers and a major global cause of mortality in men is prostate cancer (PCa). Omentin-1, an adipokine, has been shown to play a protective role by reducing proinflammatory cytokine secretion. The relationships among carcinogenic lifestyle factors, biochemical recurrence (BCR), polymorphisms, and PCa remain unclear. We investigated the impact of clinicopathological features and four gene variants on PCa risk in 701 Taiwanese male patients with and without BCR. Compared with the TT genotype, the TA+AA genotypes of SNP rs2274907 were associated with a lower risk of perineural invasion. Similarly, the AG+GG genotypes of rs4656959 were associated with a lower risk of perineural invasion compared to the AA genotype. Importantly, PCa patients without BCR exhibited the same effects. Interestingly, the wild-type TT homozygous genotype was associated with significantly lower expression levels compared to the AA genotype of the rs2274907 variant. Additionally, mRNA levels were lower in PCa tissues compared to normal tissues, indicating that omentin-1 acts as a protective factor in PCa.
前列腺癌（PCa）是男性中最常见的癌症之一，也是全球男性死亡的主要原因。网膜素-1是一种脂肪因子，已被证明通过减少促炎细胞因子分泌发挥保护作用。致癌生活方式因素、生化复发（BCR）、基因多态性与前列腺癌之间的关系仍不清楚。我们调查了701名有或无BCR的台湾男性患者的临床病理特征和四种基因变异对前列腺癌风险的影响。与TT基因型相比，单核苷酸多态性rs2274907的TA + AA基因型与神经周围浸润风险较低相关。同样，与AA基因型相比，rs4656959的AG + GG基因型与神经周围浸润风险较低相关。重要的是，无BCR的前列腺癌患者也表现出相同的效果。有趣的是，与rs2274907变异的AA基因型相比，野生型TT纯合基因型与显著较低的表达水平相关。此外，与正常组织相比，前列腺癌组织中的mRNA水平较低，表明网膜素-1在前列腺癌中起保护因子的作用。
