Lu Chang, Ma Ying, Zhao Haoyu, Zheng Yu, Zhao Qun, Lin Lili, Chen XiuZhen, Chen Linwei, Li Gang, Chen Rui
School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China.
Department of Pharmacy, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou, China.
Front Med Technol. 2025 Sep 1;7:1651390. doi: 10.3389/fmedt.2025.1651390. eCollection 2025.
The efficacy of the gypsum-licorice (SG-GC) pair was evaluated through its and anti-respiratory syncytial virus (RSV) activity. The results showed that SG-GC had significant efficacy against RSV infection in mice, which was close to that of the whole formula, and could significantly reduce the viral load in the lungs, improve the symptoms of lung injury, and reduce the inflammatory cell infiltration in the pathological sites. The decoction of single-flavored gypsum showed some anti-RSV efficacy, but not significant; when combined with sub-inhibitory concentrations of GA, it showed a significantly enhanced anti-RSV effect. The experimental results of this study suggest that gypsum may be a potential key antiviral substance, but its efficacy needs to be complemented by licorice; the significant enhancement of antiviral efficacy of SG-GC may be related to the formation of metal-organic supramolecules after the interaction of trace metal ions in gypsum and GA in licorice.
通过石膏-甘草（SG-GC）对的体外和体内抗呼吸道合胞病毒（RSV）活性评估其疗效。结果表明，SG-GC对小鼠RSV感染具有显著疗效，接近全方疗效，可显著降低肺内病毒载量，改善肺损伤症状，减少病理部位炎症细胞浸润。单味石膏水煎液显示出一定的抗RSV疗效，但不显著；与亚抑制浓度的甘草酸（GA）合用时，显示出显著增强的抗RSV效果。本研究的实验结果表明，石膏可能是潜在的关键抗病毒物质，但其疗效需要甘草来补充；SG-GC抗病毒疗效的显著增强可能与石膏中的微量金属离子与甘草中的GA相互作用后形成金属有机超分子有关。
