Misanin J R, Turns L E, Hinderliter C F
Am J Psychol. 1985 Winter;98(4):485-501.
The ability of previsual rats to acquire and retain an active avoidance response at intervals ranging from 0 min to 48 hr was examined in five experiments. Experiments 1 and 2 demonstrated that improvement in avoidance responding over trials was a training effect. Experiments 3 and 4 demonstrated that there was no evidence of retention of the avoidance response over retention intervals ranging from 15 min to 48 hr. Testing at intervals of 0-30 min in Experiment 5 indicated that 10-day-old rats could retain the response over intervals ranging from 0-15 min, but not over a 30-min interval. However, even at the very short intervals (5-15 min), there was evidence of a retention deficit. In general, the results suggest that previsual rats have sufficient memory capabilities to acquire an active avoidance response and to retain it over a 15-min interval. However, without intervention, e.g., reactivation, a retention deficit appears almost immediately, and retention loss seems complete within 30 min. This procedure and phenomenon may prove useful in allowing an immediate assessment of variables believed to alleviate retention loss and in eliminating the influence of many extraneous variables that could alter the retention performance of developing animals.
在五项实验中，研究了视觉未发育成熟的大鼠在0分钟至48小时的间隔时间内获取并保持主动回避反应的能力。实验1和实验2表明，在多次试验中回避反应的改善是一种训练效应。实验3和实验4表明，在15分钟至48小时的保持间隔时间内，没有证据表明存在回避反应的保持。实验5中在0 - 30分钟的间隔时间进行测试表明，10日龄的大鼠能够在0 - 15分钟的间隔时间内保持该反应，但不能在30分钟的间隔时间内保持。然而，即使在非常短的间隔时间（5 - 15分钟），也有保持缺陷的证据。总体而言，结果表明视觉未发育成熟的大鼠具有足够的记忆能力来获取主动回避反应并在15分钟的间隔时间内保持该反应。然而，在没有干预（例如重新激活）的情况下，保持缺陷几乎立即出现，并且在30分钟内保持丧失似乎就已完全。这一程序和现象可能有助于立即评估被认为可减轻保持丧失的变量，并消除许多可能改变发育中动物保持表现的无关变量的影响。
