Nagy Z M, Thaller K, Mazzaferri T A
Dev Psychobiol. 1977 Nov;10(6):563-73. doi: 10.1002/dev.420100610.
In Experiment I groups of mice between 16 to 100 days of age were tested for retention of a passive-avoidance response between 1 min and 96 hr following a single training trial at 2 shock intensities. In general, although almost all age groups displayed reliable retention at all retest intervals, some retention losses were found among the youngest age groups at the longer retention intervals. Higher shock intensity resulted in longer retest latencies, primarily among the youngest mice. In Experiment II mice 16, 25, and 100 days of age were trained to criterion on the passive-avoidance task and retested on a single trial following retention intervals of 24, 96, 192, and 384 hr. Young mice exhibited severe retention losses relative to 100-day-old mice at the longer intervals, even though they did not show deficiencies in acquisition. Neurological maturity at the time of original training appears to account for the age-related memory differences.
在实验I中，对16至100日龄的几组小鼠进行测试，在2种电击强度下进行单次训练试验后，于1分钟至96小时内测试其被动回避反应的保持情况。总体而言，尽管几乎所有年龄组在所有重新测试间隔中都表现出可靠的保持，但在最长的保持间隔中，最年幼的年龄组出现了一些保持能力丧失的情况。较高的电击强度导致重新测试潜伏期延长，主要出现在最年幼的小鼠中。在实验II中，对16日龄、25日龄和100日龄的小鼠进行被动回避任务训练直至达到标准，并在24小时、96小时、192小时和384小时的保持间隔后进行单次重新测试。在较长的间隔时间里，幼鼠相对于100日龄的小鼠表现出严重的保持能力丧失，尽管它们在习得方面没有表现出缺陷。初次训练时的神经成熟度似乎可以解释与年龄相关的记忆差异。
