Liu Wenyu, Yin Meng, Li Huimin
School of Physical Education, Hubei University of Automotive Technology, Shiyan, China.
Department of Sport, Dongshin University, Naju, Jeollanam-do, Republic of Korea.
Front Public Health. 2025 Sep 2;13:1623679. doi: 10.3389/fpubh.2025.1623679. eCollection 2025.
Osteoarthritis (OA) is a degenerative joint disease affecting approximately 300 million people worldwide. OA manifests as significant pain and stiffness as well as reduced mobility, substantially impacting patient quality of life and imposing considerable financial burdens on healthcare systems. Although resistance training (RT) demonstrates therapeutic potential, existing studies vary widely in its intensity, duration, and effectiveness, necessitating comprehensive dose-response analyses.
This study aimed to evaluate the effectiveness of RT interventions in the management of OA pain.
A systematic literature search was performed of the PubMed/MEDLINE, Embase, Cochrane Library, and Web of Science databases. Effect sizes were computed using Hedges'g, while the risk of bias was assessed using the Cochrane Risk of Bias 2 tool. Potential moderating factors including age, sex, and body mass index (BMI) were also analyzed.
The analysis included 28 randomized controlled trials (2,164 participants) that satisfied the inclusion criteria. RT significantly reduced OA pain compared to no intervention (Hedges'g = -0.57; 95% CrI, -0.65 to -0.49). A U-shaped dose-response relationship was observed, with an optimal weekly RT dose of 680 METs/min/week for pain relief. Higher or lower doses were less effective, and pain improvement was maintained for up to 6 months post-intervention. Age and sex were potential moderators, with more significant benefits observed in females and less favorable outcomes in older patients. BMI had no significant effect on RT efficacy.
RT constitutes an effective non-pharmacological intervention for reducing OA pain, at an optimal training dose of 680 METs/min/week. These findings emphasize the importance of considering individual patient characteristics, particularly age and sex, when prescribing RT for OA pain management.
PROSPERO, Identifier: CRD42024622698; https://www.crd.york.ac.uk/PROSPERO/view/CRD42024622698.
骨关节炎（OA）是一种退行性关节疾病，全球约有3亿人受其影响。OA表现为严重的疼痛和僵硬，以及活动能力下降，极大地影响患者的生活质量，并给医疗系统带来沉重的经济负担。尽管抗阻训练（RT）显示出治疗潜力，但现有研究在其强度、持续时间和有效性方面差异很大，因此需要进行全面的剂量反应分析。
本研究旨在评估RT干预对OA疼痛管理的有效性。
对PubMed/MEDLINE、Embase、Cochrane图书馆和Web of Science数据库进行系统的文献检索。使用Hedges'g计算效应量，同时使用Cochrane偏倚风险2工具评估偏倚风险。还分析了包括年龄、性别和体重指数（BMI）在内的潜在调节因素。
分析纳入了28项符合纳入标准的随机对照试验（2164名参与者）。与不进行干预相比，RT显著减轻了OA疼痛（Hedges'g = -0.57；95% CrI，-0.65至-0.49）。观察到一种U形剂量反应关系，缓解疼痛的最佳每周RT剂量为680 METs/分钟/周。更高或更低的剂量效果较差，干预后长达6个月疼痛改善得以维持。年龄和性别是潜在的调节因素，女性受益更显著，老年患者的结果不太理想。BMI对RT疗效没有显著影响。
RT是一种有效的非药物干预措施，可减轻OA疼痛，最佳训练剂量为680 METs/分钟/周。这些发现强调了在为OA疼痛管理开具RT处方时考虑个体患者特征，特别是年龄和性别的重要性。
PROSPERO，标识符：CRD42024622698；https://www.crd.york.ac.uk/PROSPERO/view/CRD42024622698 。
