Di Wenli, Sun Fengjiao, Gao Xibao
Department of Health Inspection and Quarantine, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China.
School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China.
Int J Prev Med. 2025 Aug 26;16:53. doi: 10.4103/ijpvm.ijpvm_380_24. eCollection 2025.
A high-fat diet (HFD) significantly contributes to the development of chronic diseases, which have become a major public health concern. These diseases affect individuals' health and quality of life and hinder socioeconomic progress. Trace elements (TEs) are crucial in various physiological and biochemical processes. Although the effects of single or a few TEs have been extensively reported, considering the complex interactions between different TEs, the effects of balanced supplementation of multiple TEs still need further investigation.
In this research, 11 TEs (B, V, Cr, Mn, Fe, Co, Cu, Zn, Se, Sr, and Mo) were selected and prepared as a mixed solution in specific proportions to supplement rats. The study investigated the effects of balanced supplementation of multiple TEs on inflammation, oxidative stress, and immune function in rats fed an HFD.
The results demonstrated that supplementing multiple TEs had several positive effects, including increased lipid metabolism in HFD rats, improved dyslipidemia, reduced weight and obesity incidence, enhanced antioxidant enzyme activity, and improved anti-inflammatory capacity.
Therefore, the balanced supplementation of various TEs is expected to become an effective method to prevent and control the harmful effects of HFD.
高脂饮食（HFD）显著促进了慢性疾病的发展，这些疾病已成为主要的公共卫生问题。这些疾病影响个人健康和生活质量，并阻碍社会经济发展。微量元素（TEs）在各种生理和生化过程中至关重要。尽管单一或少数几种微量元素的作用已被广泛报道，但考虑到不同微量元素之间复杂的相互作用，多种微量元素平衡补充的效果仍需进一步研究。
在本研究中，选择了11种微量元素（硼、钒、铬、锰、铁、钴、铜、锌、硒、锶和钼），并按特定比例配制成混合溶液来补充给大鼠。该研究调查了多种微量元素平衡补充对高脂饮食喂养大鼠的炎症、氧化应激和免疫功能的影响。
结果表明，补充多种微量元素有多种积极作用，包括提高高脂饮食大鼠的脂质代谢、改善血脂异常、降低体重和肥胖发生率、增强抗氧化酶活性以及提高抗炎能力。
因此，各种微量元素的平衡补充有望成为预防和控制高脂饮食有害影响的有效方法。
