Kheirkhah Mina, McDonald Nastasia, Aepfelbacher Julia, Rengasamy Manivel L, Shivanekar Sharvari, Spotts Crystal, Cooper Iya, Baumeister Andrew, Bell Elizabeth, Do-Nguyen Kevin, Woody Mary L, Hossein Shabnam, Henter Ioline D, Nugent Allison C, Hejazi Nadia S, Jamalabadi Hamidreza, Yavi Mani, Walter Martin, Zarate Carlos A, Price Rebecca B
Experimental Therapeutics and Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States.
Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany.
Front Psychiatry. 2025 Sep 2;16:1642025. doi: 10.3389/fpsyt.2025.1642025. eCollection 2025.
This is the first randomized controlled trial to use both qualitative and quantitative methods to evaluate the effects of a combined sensory intervention that included mindfulness, music, and a light-occluding eye mask during antidepressant-dose ketamine treatment for depression.
Forty-three participants with unipolar depressive disorder enrolled in the study; 22 individuals were randomly assigned to receive mindfulness, music, and eye mask during ketamine infusion, and 21 individuals in the control group received only ketamine without additional interventions. Quantitative analyses assessed the impact of combined sensory intervention on ketamine's antidepressant effects, and qualitative analyses explored the participants' experiences.
Depression scores improved significantly and similarly across both groups. However, adding combined sensory interventions to ketamine infusion enriched subjective experience. More participants in the combined sensory intervention group reported deeper engagement, a stronger sense of connection to reality, increased focus on the experience rather than the strangeness of it, moments of relief from sadness, and feelings of awe and spiritual insight compared to the control group. Four individuals in the combined sensory intervention group also reported discomfort.
Ketamine's antidepressant effects remained consistent with or without combined sensory intervention; however, mindfulness, music, and eye mask made the experience more meaningful and emotionally rich for many, though it also introduced discomfort for a few-this outcome might be avoided by making these interventions optional. Given the limited research on combining ketamine with sensory interventions, these results contribute valuable insights and underscore the need for further studies to explore this combined therapeutic approach.
https://clinicaltrials.gov/study/NCT05168735, identifier NCT05168735.
这是第一项采用定性和定量方法评估联合感官干预效果的随机对照试验，该联合感官干预包括在抗抑郁剂量的氯胺酮治疗抑郁症期间进行正念训练、音乐疗法和使用遮光眼罩。
43名单相抑郁症患者参与了该研究；22名个体被随机分配在氯胺酮输注期间接受正念训练、音乐疗法和使用眼罩，21名对照组个体仅接受氯胺酮治疗，无额外干预。定量分析评估联合感官干预对氯胺酮抗抑郁效果的影响，定性分析探索参与者的体验。
两组的抑郁评分均显著且相似地改善。然而，在氯胺酮输注中加入联合感官干预丰富了主观体验。与对照组相比，联合感官干预组更多参与者报告参与度更高、与现实的联系感更强、对体验的关注度增加而非对其陌生感的关注、悲伤情绪的缓解时刻以及敬畏和精神洞察的感觉。联合感官干预组中有4人也报告了不适。
无论是否进行联合感官干预，氯胺酮的抗抑郁效果保持一致；然而，正念训练、音乐疗法和眼罩使许多人的体验更有意义且情感更丰富，尽管也有少数人感到不适——通过使这些干预成为可选项目，可能避免这种结果。鉴于氯胺酮与感官干预结合的研究有限，这些结果提供了有价值的见解，并强调需要进一步研究探索这种联合治疗方法。
https://clinicaltrials.gov/study/NCT05168735，标识符NCT05168735。
