Zhang Zhaoqing, Ma Haiyan, Tian Ruisong, Li Guangwei, Zhao Fuchang, Xie Liangyu, Chen Hao
Neck-Shoulder and Lumbocrural Pain Hospital of Shandong First Medical University, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China.
College of Medical Information and Artificial Intelligence, Shandong First Medical University, Jinan, China.
Front Bioeng Biotechnol. 2025 Sep 2;13:1655686. doi: 10.3389/fbioe.2025.1655686. eCollection 2025.
Spinal Cord Injury (SCI) leads to severe motor and sensory impairments and underscores the urgent need for the development of effective treatment approaches. The injury microenvironment with oxidation, inflammation and extracellular matrix disruption represents a major barrier to nerve tissue repair as well as the functioning of therapeutic factors.
This study proposes a curcumin-loaded boronate-crosslinked tannic acid injectable hydrogel (CBT-gel) for effective antioxidants and neuroprotective spinal cord repair. Rat transection SCI models were established, and the CBT-gel was implanted in the injured spinal cord tissue. Behavioral and histological testing was performed to determine the spinal cord repair effects.
The injectable self-healing hydrogel induced sustainable release of the neuroprotective drug curcumin. The CBT-gel transplantation treatment enhanced axonal preservation and reduced glial scar formation. The results also revealed a reduction in neuroinflammation and cellular oxidative damage.
These findings support the potential of CBT-gel to improve the microenvironment for spinal cord repair by leveraging their antioxidant and neuroprotective properties. The results in this study aligns with the documented bioactivity of curcumin, though molecular targets in the CBT-gel treatment require further profiling.
脊髓损伤（SCI）会导致严重的运动和感觉障碍，凸显了开发有效治疗方法的迫切需求。具有氧化、炎症和细胞外基质破坏的损伤微环境是神经组织修复以及治疗因子发挥作用的主要障碍。
本研究提出一种负载姜黄素的硼酸交联单宁酸可注射水凝胶（CBT-凝胶），用于有效的抗氧化和神经保护脊髓修复。建立大鼠横断性脊髓损伤模型，并将CBT-凝胶植入受损脊髓组织。进行行为和组织学测试以确定脊髓修复效果。
可注射的自愈水凝胶可诱导神经保护药物姜黄素的持续释放。CBT-凝胶移植治疗增强了轴突保留并减少了胶质瘢痕形成。结果还显示神经炎症和细胞氧化损伤有所减少。
这些发现支持CBT-凝胶通过利用其抗氧化和神经保护特性来改善脊髓修复微环境的潜力。本研究结果与姜黄素已记录的生物活性一致，尽管CBT-凝胶治疗中的分子靶点需要进一步分析。
