Paraskevopoulos Alexandros, Wettermark Björn, Bouloukaki Izolde, Tsiligianni Ioanna
Department of Social Medicine, School of Medicine, University of Crete, Heraklion, GRC.
Department of Pharmacy, Faculty of Pharmacy, Uppsala University, Uppsala, SWE.
Cureus. 2025 Sep 16;17(9):e92451. doi: 10.7759/cureus.92451. eCollection 2025 Sep.
Background Deprescribing is a key strategy to combat polypharmacy and enhance clinical outcomes. However, successful deprescribing interventions are significantly influenced by the patient's attitudes, beliefs, and preferences. The aim of this study was to translate and validate into Greek the revised Patients' Attitudes Towards Deprescribing (rPATD) questionnaire, which assesses the attitudes and beliefs of older adults about deprescribing. Methods The rPATD questionnaire for older adults was translated using forward-backward translation into Greek. To evaluate psychometric properties, older adults aged ≥65 years taking at least five medications were recruited from 15 primary care facilities in Heraklion, Crete, Greece. Construct validity was examined through exploratory factor analysis (EFA). Reliability was assessed through internal consistency, measured by Cronbach's alpha and item-total correlations, as well as test-retest reliability, determined by the intra-class correlation coefficient (ICC) and weighted kappa coefficient. Floor and ceiling effects were examined. Results A total of 255 participants completed the questionnaire. Consistent with the English rPATD, EFA revealed a four-factor structure addressing beliefs about medication appropriateness, perceived medication burden, the level of involvement in medication management, and concerns about stopping medication. Acceptable internal consistency was indicated by Cronbach's alpha values, which ranged from 0.691 to 0.840. Test-retest reliability was satisfactory for all factors, with ICC values ranging from 0.702 to 0.962. A substantial ceiling effect was observed in the involvement factor, while no factor exhibited a significant floor effect. Conclusions The Greek adaptation of the rPATD demonstrated psychometric soundness and provides a valid and reliable tool for evaluating attitudes towards deprescribing among older adults.
背景 减药是应对多重用药并改善临床结局的一项关键策略。然而，成功的减药干预措施会受到患者态度、信念和偏好的显著影响。本研究的目的是将修订后的患者对减药的态度（rPATD）问卷翻译成希腊语并进行验证，该问卷用于评估老年人对减药的态度和信念。方法 采用正向-反向翻译法将老年人rPATD问卷翻译成希腊语。为评估心理测量特性，从希腊克里特岛伊拉克利翁的15家初级保健机构招募了年龄≥65岁且服用至少五种药物的老年人。通过探索性因素分析（EFA）检验结构效度。通过内部一致性评估信度，采用克朗巴哈α系数和项目-总分相关性进行测量，同时通过组内相关系数（ICC）和加权卡帕系数确定重测信度。检查地板效应和天花板效应。结果 共有255名参与者完成了问卷。与英文rPATD一致，EFA揭示了一个四因素结构，涉及对用药合理性的信念、感知到的用药负担、参与用药管理的程度以及对停药的担忧。克朗巴哈α系数值表明内部一致性可接受，范围为0.691至0.840。所有因素的重测信度均令人满意，ICC值范围为0.702至0.962。在参与因素中观察到显著的天花板效应，而没有因素表现出显著的地板效应。结论 rPATD的希腊语改编版显示出心理测量的稳健性，并为评估老年人对减药的态度提供了一个有效且可靠的工具。
