Shan Zhaozhao, Liu Jianjian, Shang Ruikai, Liu Hongyu, Tian Qiaoxin, Liu Yuru, Zheng Yingying, Jian Xiangdong, Kan Baotian
Department of Occupational and Environmental Health, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China.
Department of Poisoning and Occupational Diseases, Emergency Medicine, Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, China.
Front Med (Lausanne). 2025 Sep 3;12:1667174. doi: 10.3389/fmed.2025.1667174. eCollection 2025.
In March 2025, a rare incident of acute group poisoning due to naphtha vapor inhalation occurred in Shandong, China. This study aimed to analyze the clinical data of patients exposed to mixed asphyxiating gases to enhance awareness of relevant personnel in industrial production and emergency medical staff.
An on-site investigation and laboratory testing were conducted to examine the poisoning incident. The clinical data of three patients poisoned by asphyxiating gases after inhaling naphtha vapor were retrospectively analyzed.
Patients were primarily exposed to naphtha vapor through the respiratory tract. The main clinical manifestations were respiratory failure and neurological symptoms, such as impaired consciousness. Chest computed tomography and cranial magnetic resonance imaging revealed varying degrees of injury in all three patients, primarily characterized by hypoxic-ischemic brain lesions, pulmonary inflammation, and exudation. Laboratory tests showed arterial blood gas hypoxemia, abnormal white blood cell count, and an increased neutrophil ratio. After mechanical ventilation, glucocorticoid pulse therapy, and neurotrophic treatment, one patient recovered fully within 7 days, one exhibited persistent decorticate symptoms, and one continued to experience respiratory failure requiring mechanical ventilation. All three patients survived.
Inhalation of naphtha vapor led to varying degrees of respiratory failure and neurological impairment in all three patients. Based on on - site sampling analysis and laboratory tests, it was determined that this incident was a poisoning incident caused by inhalation of a mixed gas mainly composed of hydrogen sulfide and alkane gases due to non - compliant operations. Early electrocardiogram monitoring combined with imaging evaluation played a crucial role in guiding clinical management and improving outcomes.
2025年3月，中国山东发生了一起因吸入石脑油蒸气导致的罕见急性群体中毒事件。本研究旨在分析接触混合窒息性气体患者的临床资料，以提高工业生产相关人员及急诊医护人员的认识。
对该中毒事件进行了现场调查和实验室检测。回顾性分析了3例吸入石脑油蒸气后窒息性气体中毒患者的临床资料。
患者主要通过呼吸道接触石脑油蒸气。主要临床表现为呼吸衰竭和神经症状，如意识障碍。胸部计算机断层扫描和头颅磁共振成像显示，所有3例患者均有不同程度的损伤，主要表现为缺氧缺血性脑损伤、肺部炎症和渗出。实验室检查显示动脉血气低氧血症、白细胞计数异常及中性粒细胞比例升高。经过机械通气、糖皮质激素冲击治疗和神经营养治疗后，1例患者在7天内完全康复，1例表现为持续性去皮质症状，1例继续出现呼吸衰竭需要机械通气。3例患者均存活。
吸入石脑油蒸气导致所有3例患者均出现不同程度的呼吸衰竭和神经功能损害。通过现场采样分析和实验室检测，确定该事件是一起因操作不合规导致吸入以硫化氢和烷烃气体为主的混合气体引起的中毒事件。早期心电图监测结合影像学评估对指导临床治疗及改善预后起到了关键作用。
