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纳尔逊湾病毒的结构与细胞病变效应

Structure and cytopathic effects of Nelson Bay virus.

作者信息

Gard G, Compans R W

出版信息

J Virol. 1970 Jul;6(1):100-6. doi: 10.1128/JVI.6.1.100-106.1970.

DOI:10.1128/JVI.6.1.100-106.1970
PMID:4097231
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC376095/
Abstract

A virus isolated from a flying fox (Pteropus poliocephalus) has a morphology similar to that of reoviruses. However, unlike the reoviruses, this virus has a rapid cytopathic effect, causing cell fusion, vacuolization of the cytoplasm, and an unusual nuclear degeneration. Immunofluorescence indicates that viral antigen is distributed through both nucleus and cytoplasm. Viral maturation appears to take place in discrete cytoplasmic factories, and there is no apparent involvement of spindle tubules.

摘要

从狐蝠（灰头狐蝠）分离出的一种病毒，其形态与呼肠孤病毒相似。然而，与呼肠孤病毒不同的是，这种病毒具有快速的细胞病变效应，可导致细胞融合、细胞质空泡化以及异常的核变性。免疫荧光显示病毒抗原分布于细胞核和细胞质中。病毒成熟似乎发生在离散的细胞质工厂中，且纺锤体微管未明显参与其中。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c157/376095/0faead89d964/jvirol00295-0115-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c157/376095/64174d5f746b/jvirol00295-0111-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c157/376095/211de8071697/jvirol00295-0112-a.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c157/376095/bf7790e399de/jvirol00295-0113-b.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c157/376095/0faead89d964/jvirol00295-0115-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c157/376095/64174d5f746b/jvirol00295-0111-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c157/376095/211de8071697/jvirol00295-0112-a.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c157/376095/7876475afc41/jvirol00295-0113-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c157/376095/bf7790e399de/jvirol00295-0113-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c157/376095/6ad1d2d0dff0/jvirol00295-0114-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c157/376095/0faead89d964/jvirol00295-0115-a.jpg

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本文引用的文献

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Virology. 1961 Dec;15:428-35. doi: 10.1016/0042-6822(61)90110-6.
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Cytochemical, fluorescent-antibody and electron microscopic studies on the growth of reovirus (ECHO 10) in tissue culture.关于呼肠孤病毒（艾柯病毒10型）在组织培养中生长的细胞化学、荧光抗体及电子显微镜研究。
Virology. 1962 Jun;17:342-55. doi: 10.1016/0042-6822(62)90125-3.
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THE UPTAKE AND DEVELOPMENT OF REOVIRUS IN STRAIN L CELLS FOLLOWED WITH LABELED VIRAL RIBONUCLEIC ACID AND FERRITIN-ANTIBODY CONJUGATES.
中国云南省蝙蝠和吸血节肢动物中分离的纳尔逊湾呼肠孤病毒。
Microbiol Spectr. 2023 Aug 17;11(4):e0512222. doi: 10.1128/spectrum.05122-22. Epub 2023 Jun 12.
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Pteropine orthoreoviruses use cell surface heparan sulphate as an attachment receptor.食虫蝙蝠正呼肠孤病毒利用细胞表面的肝素硫酸盐作为附着受体。
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