Barbanti-Brodano G, Swetly P, Koprowski H
J Virol. 1970 Jul;6(1):78-86. doi: 10.1128/JVI.6.1.78-86.1970.
The early events in the interaction of simian virus 40 (SV40) with permissive cells were investigated. Evidence is presented that 30 min after infection intact virions penetrate the nuclei of infected cells. The uncoating of the virus is carried out in the nuclei with a complete dissociation of the viral genome from the protein coat. Opening of the circular parental deoxyribonucleic acid (DNA), i.e., conversion of component I to component II of SV40 DNA, takes place after uncoating, followed by the appearance of a new component sedimenting faster than component I at alkaline pH.
对猿猴病毒40(SV40)与允许性细胞相互作用的早期事件进行了研究。有证据表明,感染后30分钟,完整的病毒粒子穿透被感染细胞的细胞核。病毒在细胞核内进行脱壳,病毒基因组与蛋白质外壳完全解离。环状亲代脱氧核糖核酸(DNA),即SV40 DNA的组分I向组分II的转化,在脱壳后发生,随后在碱性pH条件下出现一种沉降速度比组分I快的新组分。