Abdelwahab Siddig Ibrahim, Taha Manal Mohamed Elhassan, Farasani Abdullah, Abdullah Saleh M, Moshi Jobran M, Khamjan Nizar A, Assiri Ahmad, Alshahrani Saeed, Sahli Khaled A, Qadri Marwa, Hassan Waseem
Jazan University, Jazan, Saudi Arabia.
Ministry of Interior, Riyadh, Saudi Arabia.
Lasers Med Sci. 2025 Sep 20;40(1):371. doi: 10.1007/s10103-025-04647-w.
Laser therapy is a key acne treatment, yet no bibliometric study has integrated advanced metrics, co-word dynamics, keyword clustering, and citation analysis of the top 100 papers. Three Scopus search strategies were used, and the top 100 most cited papers were analyzed for descriptive statistics and citation impact. The Title-Abstract-Keyword (TAK) search identified 2,352 papers, with output increasing steadily from 2004 and reaching a peak in 2024 (187 papers). The Abstract-only search retrieved 1,209 papers, also peaking in 2024 (98 papers), while the Title-only search yielded 468 papers, with the highest output in 2021 (39 papers). The 100 most cited papers, published between 1986 and 2021, were drawn from 35 sources and comprised 86 original articles and 14 reviews. These papers exhibited no annual growth, had an average age of 16 years, and received an average of 71.54 citations each. From this title-based analysis, several clear research foci emerged: (1) laser resurfacing and fractional CO₂ laser therapy for atrophic acne scars, including comparative trials with Er: YAG and Nd: YAG lasers; (2) pulsed dye lasers and photodynamic therapy for inflammatory acne; (3) diode and nonablative fractional lasers for reducing sebum production and treating scars in diverse skin types; (4) platelet-rich plasma and radiofrequency microneedling as adjuncts to laser therapy to enhance collagen remodeling; and (5) emerging modalities such as picosecond, indocyanine-green, and 675-nm lasers for targeted acne management. These focal areas represent the primary thematic directions of the most influential studies in the field. This first comprehensive bibliometric analysis of laser therapy for acne identifies fractional CO₂ lasers, nonablative fractional lasers, and combination therapies as dominant research themes, while highlighting emerging modalities such as picosecond and 675-nm lasers. These findings align with current clinical priorities and provide a data-driven roadmap for future therapeutic innovation.
激光疗法是治疗痤疮的关键方法，但尚无文献计量学研究整合前100篇论文的高级指标、共词动态、关键词聚类和引文分析。我们采用了三种Scopus搜索策略，并对被引频次最高的100篇论文进行描述性统计和引文影响力分析。标题-摘要-关键词（TAK）搜索共识别出2352篇论文，其产出自2004年起稳步增长，并于2024年达到峰值（187篇）。仅摘要搜索检索到1209篇论文，同样在2024年达到峰值（98篇），而仅标题搜索产生了468篇论文，在2021年产出最高（39篇）。这100篇被引频次最高的论文发表于1986年至2021年间，来自35个来源，包括86篇原创文章和14篇综述。这些论文没有呈现出年度增长趋势，平均发表年限为16年，每篇论文平均被引71.54次。基于此标题分析，出现了几个明确的研究重点：（1）用于萎缩性痤疮瘢痕的激光换肤和剥脱性二氧化碳激光疗法，包括与铒：钇铝石榴石激光和钕：钇铝石榴石激光的对比试验；（2）用于炎性痤疮的脉冲染料激光和光动力疗法；（3）用于减少不同皮肤类型皮脂分泌和治疗瘢痕的二极管激光和非剥脱性分次激光；（4）富含血小板血浆和射频微针作为激光治疗的辅助手段以增强胶原蛋白重塑；（5）如皮秒激光、吲哚菁绿激光和675纳米激光等新兴治疗方式用于针对性痤疮管理。这些重点领域代表了该领域最具影响力研究的主要主题方向。这项首次针对痤疮激光治疗的全面文献计量分析确定了剥脱性二氧化碳激光、非剥脱性分次激光和联合治疗为主要研究主题，同时突出了皮秒激光和675纳米激光等新兴治疗方式。这些发现与当前临床重点一致，并为未来治疗创新提供了数据驱动的路线图。
