Muranaka Yosuke, Nishimuro Yukako, Maki Taisuke
Department of Chemical Engineering, Kyoto University, Kyoto 615-8510, Japan.
ACS Omega. 2025 Sep 4;10(36):41214-41220. doi: 10.1021/acsomega.5c03957. eCollection 2025 Sep 16.
The one-pot synthesis of chitosan gel-encapsulated gold nanoparticles (AuNPs) was investigated by using an inkjet mixing system. Through the collision of microdroplets, AuNPs with an average diameter of 5.1 nm and a coefficient of variation of 0.19 were successfully synthesized via a reduction method. In the synthesis of chitosan capsules, it was found that the type of gelling agent influences the diameter and particle size distribution of the resulting capsules due to their reaction rates. Utilizing the advantages of the inkjet mixing system, the one-pot synthesis of chitosan gel-encapsulated AuNPs was successfully achieved. It was found that the time between the nucleation of AuNPs and gelation was critical for encapsulation. It was thus demonstrated that the potential of the inkjet mixing system can be expanded to the synthesis of various types of nanoscale products by designing the process and that the system can be a powerful tool to reveal the mechanism of nanoparticle synthesis by precisely tuning the conditions.
通过使用喷墨混合系统研究了壳聚糖凝胶包裹金纳米颗粒（AuNPs）的一锅法合成。通过微滴碰撞，采用还原法成功合成了平均直径为5.1 nm、变异系数为0.19的AuNPs。在壳聚糖胶囊的合成中，发现由于胶凝剂的反应速率，其类型会影响所得胶囊的直径和粒径分布。利用喷墨混合系统的优势，成功实现了壳聚糖凝胶包裹AuNPs的一锅法合成。发现AuNPs成核与凝胶化之间的时间对包封至关重要。因此证明，通过设计工艺，喷墨混合系统的潜力可以扩展到各种类型纳米级产品的合成，并且该系统可以成为通过精确调节条件来揭示纳米颗粒合成机制的强大工具。
