Suktong Kunnipa, Phasi Jirawan, Longsomboon Phatthaphorn, Chumkasorn Virunchana, Sane Amporn, Wadaugsorn Kiattichai
Department of Packaging and Materials Technology, Faculty of Agro-Industry, Kasetsart University, Bangkok 10900, Thailand.
ACS Omega. 2025 Sep 3;10(36):42092-42101. doi: 10.1021/acsomega.5c07499. eCollection 2025 Sep 16.
2,5-Furandicarboxylic acid (FDCA) is a promising biobased monomer offering a sustainable alternative to polyethylene terephthalate (PET). However, its production remains limited by conventional reactors, which require severe operating conditions and lack optimized reaction parameters, hindering efficiency. This study investigates the synthesis of FDCA from the oxidation of 5-hydroxymethylfurfural (HMF) in a continuous packed-bed reactor using Ru/C as a catalyst and HO as an oxidant. The effects of the HMF/NaOH molar ratio and the flow rates of HMF and HO on product yield are investigated and analyzed using HPLC. Higher HMF flow rates led to intermediate accumulation due to insufficient contact time, while the lowest flow rate (0.01 mL/min) facilitated the complete conversion to FDCA without intermediates. An increase in the HO flow rate (0.05 mL/min) reduced the FDCA yield, likely due to oxidative limitations and catalyst deactivation. Optimal conditions, an HMF/NaOH/HO molar ratio of 1:12:8, HMF and HO flow rates of 0.03 mL/min, 75 °C, and 1 bar, achieved an FDCA yield of 81.5%. The packed-bed reactor enhanced FDCA production efficiency, yielding an 8.5-fold increase while reducing reaction time compared to a conventional reactor under mild operating conditions. These findings highlight the potential of continuous-flow reactors for efficient and scalable FDCA production.
2,5-呋喃二甲酸（FDCA）是一种很有前景的生物基单体，为聚对苯二甲酸乙二酯（PET）提供了一种可持续的替代品。然而，其生产仍然受到传统反应器的限制，传统反应器需要苛刻的操作条件且缺乏优化的反应参数，从而阻碍了效率。本研究考察了以Ru/C为催化剂、HO为氧化剂，在连续填充床反应器中由5-羟甲基糠醛（HMF）氧化合成FDCA的过程。使用高效液相色谱法（HPLC）研究并分析了HMF/NaOH摩尔比以及HMF和HO的流速对产物产率的影响。较高的HMF流速由于接触时间不足导致中间体积累，而最低流速（0.01 mL/min）则有利于完全转化为FDCA且无中间体生成。HO流速增加（0.05 mL/min）会降低FDCA产率，这可能是由于氧化限制和催化剂失活所致。最佳条件为HMF/NaOH/HO摩尔比1:12:8、HMF和HO流速0.03 mL/min、75℃和1巴，此时FDCA产率达到81.5%。在温和的操作条件下，填充床反应器提高了FDCA的生产效率，与传统反应器相比，产率提高了8.5倍，同时缩短了反应时间。这些发现突出了连续流反应器在高效且可扩展的FDCA生产方面的潜力。
