Chen Ruiqi, Xu Hongbiao, Li Xueshi, Dong Jie, Wang Shengli, Hao Jianlei, Liang Guangping
The Affiliated Guangdong Second Provincial General Hospital of Jinan University, No. 466, Middle Xingang Road, Haizhu District, Guangzhou, Guangdong 510317, China.
State Key Laboratory of Bioactive Molecules and Druggability Assessment, The Biomedical Translational Research Institute, Health Science Center (School of Medicine), Jinan University, No. 601 Huangpu Avenue West, Tianhe District, Guangzhou, Guangdong 510632, China.
Burns Trauma. 2025 Jun 11;13:tkaf040. doi: 10.1093/burnst/tkaf040. eCollection 2025.
Oxidative stress is an inherent pathophysiological feature in burn wound healing. Severe burns trigger rapid changes in patients' conditions, leading to ischemia-reperfusion injury from early fluid resuscitation, neuroendocrine stress, and fluid imbalances, which exacerbate oxidative damage and organ dysfunction. This review highlights the critical role of oxidative stress in post-burn wound healing, its potential to cause cellular and tissue damage, and oxidative stress mechanisms. Antioxidant therapy is recommended as a cost-effective method of modulating inflammation and burn outcome. Preparative measures of successful antioxidant therapy should be developed in improving burn patients' wound healing.
氧化应激是烧伤创面愈合过程中固有的病理生理特征。严重烧伤会引发患者病情的迅速变化，导致早期液体复苏、神经内分泌应激和液体失衡引起的缺血-再灌注损伤，这会加剧氧化损伤和器官功能障碍。本综述强调了氧化应激在烧伤后创面愈合中的关键作用、其导致细胞和组织损伤的可能性以及氧化应激机制。抗氧化治疗被推荐为一种调节炎症和改善烧伤预后的经济有效的方法。应制定成功进行抗氧化治疗的准备措施，以改善烧伤患者的创面愈合。
