• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

涉及环庚三烯酮的环加成和官能团化反应。

Cycloaddition and functionalization reactions involving tropone.

作者信息

Doraghi Fatemeh, Edareh Mohammad Hadi, Larijani Bagher, Mahdavi Mohammad

机构信息

Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences Tehran Iran

School of Chemistry, College of Science, University of Tehran Tehran Iran.

出版信息

RSC Adv. 2025 Sep 19;15(41):34282-34299. doi: 10.1039/d5ra05481h. eCollection 2025 Sep 17.

DOI:10.1039/d5ra05481h
PMID:40979965
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12447263/
Abstract

Tropones are valuable moieties in the synthesis of natural products and bioactive molecules. Tropones have also emerged as fascinating synthetic partners for various (4 + 2)-, (4 + 6)-, (6 + 3)-, (6 + 4)-, (6 + 6)-, (8 + 2)-, and (8 + 3)-cycloaddition reactions as well as functionalization reactions. This review highlights various cycloaddition and functionalization reactions involving tropone building blocks reported since 2014.

摘要

卓酚酮在天然产物和生物活性分子的合成中是有价值的部分。卓酚酮也已成为各种（4 + 2）-、（4 + 6）-、（6 + 3）-、（6 + 4）-、（6 + 6）-、（8 + 2）-和（8 + 3）-环加成反应以及官能团化反应中引人入胜的合成伙伴。本综述重点介绍了自2014年以来报道的涉及卓酚酮结构单元的各种环加成和官能团化反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe4/12447263/c939403da83f/d5ra05481h-s35.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe4/12447263/07d2bb4aa984/d5ra05481h-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe4/12447263/fb9c6721d4a5/d5ra05481h-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe4/12447263/95d874c6ab9e/d5ra05481h-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe4/12447263/759d77c18185/d5ra05481h-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe4/12447263/d11e31824bdb/d5ra05481h-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe4/12447263/1d169396e01f/d5ra05481h-s4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe4/12447263/926881859875/d5ra05481h-s5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe4/12447263/62cc40345e96/d5ra05481h-s6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe4/12447263/7e2108364e6d/d5ra05481h-s7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe4/12447263/297e87ac84a5/d5ra05481h-s8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe4/12447263/276fa2d8304b/d5ra05481h-s9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe4/12447263/21a80cc4f7fa/d5ra05481h-s10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe4/12447263/155a0c4a563f/d5ra05481h-s11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe4/12447263/9e1ded1cea1a/d5ra05481h-s12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe4/12447263/f18487deb494/d5ra05481h-s13.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe4/12447263/4fa2aff831d7/d5ra05481h-s14.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe4/12447263/725164866c18/d5ra05481h-s15.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe4/12447263/05f83116a572/d5ra05481h-s16.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe4/12447263/6f5d814f5360/d5ra05481h-s17.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe4/12447263/4629e42fc4ae/d5ra05481h-s18.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe4/12447263/e012ac2a8e97/d5ra05481h-s19.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe4/12447263/6249eee42b37/d5ra05481h-s20.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe4/12447263/3d95f9c63908/d5ra05481h-s21.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe4/12447263/9fca833da6ad/d5ra05481h-s22.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe4/12447263/105759d1bbfd/d5ra05481h-s23.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe4/12447263/753245854dfd/d5ra05481h-s25.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe4/12447263/6c09b4e6d492/d5ra05481h-s27.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe4/12447263/0944174ee554/d5ra05481h-s29.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe4/12447263/2b7c92f21fd0/d5ra05481h-s31.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe4/12447263/181b67654a64/d5ra05481h-s33.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe4/12447263/c939403da83f/d5ra05481h-s35.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe4/12447263/07d2bb4aa984/d5ra05481h-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe4/12447263/fb9c6721d4a5/d5ra05481h-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe4/12447263/95d874c6ab9e/d5ra05481h-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe4/12447263/759d77c18185/d5ra05481h-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe4/12447263/d11e31824bdb/d5ra05481h-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe4/12447263/1d169396e01f/d5ra05481h-s4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe4/12447263/926881859875/d5ra05481h-s5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe4/12447263/62cc40345e96/d5ra05481h-s6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe4/12447263/7e2108364e6d/d5ra05481h-s7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe4/12447263/297e87ac84a5/d5ra05481h-s8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe4/12447263/276fa2d8304b/d5ra05481h-s9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe4/12447263/21a80cc4f7fa/d5ra05481h-s10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe4/12447263/155a0c4a563f/d5ra05481h-s11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe4/12447263/9e1ded1cea1a/d5ra05481h-s12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe4/12447263/f18487deb494/d5ra05481h-s13.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe4/12447263/4fa2aff831d7/d5ra05481h-s14.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe4/12447263/725164866c18/d5ra05481h-s15.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe4/12447263/05f83116a572/d5ra05481h-s16.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe4/12447263/6f5d814f5360/d5ra05481h-s17.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe4/12447263/4629e42fc4ae/d5ra05481h-s18.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe4/12447263/e012ac2a8e97/d5ra05481h-s19.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe4/12447263/6249eee42b37/d5ra05481h-s20.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe4/12447263/3d95f9c63908/d5ra05481h-s21.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe4/12447263/9fca833da6ad/d5ra05481h-s22.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe4/12447263/105759d1bbfd/d5ra05481h-s23.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe4/12447263/753245854dfd/d5ra05481h-s25.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe4/12447263/6c09b4e6d492/d5ra05481h-s27.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe4/12447263/0944174ee554/d5ra05481h-s29.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe4/12447263/2b7c92f21fd0/d5ra05481h-s31.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe4/12447263/181b67654a64/d5ra05481h-s33.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe4/12447263/c939403da83f/d5ra05481h-s35.jpg

相似文献

1
Cycloaddition and functionalization reactions involving tropone.涉及环庚三烯酮的环加成和官能团化反应。
RSC Adv. 2025 Sep 19;15(41):34282-34299. doi: 10.1039/d5ra05481h. eCollection 2025 Sep 17.
2
Prescription of Controlled Substances: Benefits and Risks管制药品的处方：益处与风险
3
Accessing diverse fluorinated organic molecules by fluoro-functionalization reactions of enaminones.通过烯胺酮的氟官能化反应获取多种含氟有机分子。
Chem Commun (Camb). 2025 Sep 9;61(73):13852-13863. doi: 10.1039/d5cc04020e.
4
Fluorinated Radicals in Divergent Synthesis via Photoredox Catalysis.通过光氧化还原催化进行发散合成中的氟化自由基
Acc Chem Res. 2025 Jul 1;58(13):2046-2060. doi: 10.1021/acs.accounts.5c00239. Epub 2025 Jun 11.
5
Indole-2-carboxamide: a versatile synthetic handle for the synthesis of diversely substituted polycyclic indole structures.吲哚-2-甲酰胺：用于合成多种取代的多环吲哚结构的通用合成基团。
Org Biomol Chem. 2025 Jul 2;23(26):6256-6286. doi: 10.1039/d5ob00761e.
6
Light-Driven C(sp)-C(sp) Bond Functionalizations Enabled by the PCET Activation of Alcohol O-H Bonds.通过醇O-H键的PCET活化实现光驱动的C(sp)-C(sp)键官能团化
Acc Chem Res. 2025 Jul 1;58(13):2061-2071. doi: 10.1021/acs.accounts.5c00246. Epub 2025 Jun 13.
7
Hydrogen Atom Transfer Promoted by Carbon-Centered Biradicals via Energy Transfer Catalysis.以碳为中心的双自由基通过能量转移催化促进氢原子转移
Acc Chem Res. 2025 Jul 1;58(13):2028-2045. doi: 10.1021/acs.accounts.5c00228. Epub 2025 Jun 9.
8
Stereoselective Nondirected α-C(sp)-H Functionalization of Oxygen Heterocycles.氧杂环的立体选择性非定向α-C(sp)-H官能团化
Acc Chem Res. 2025 Aug 5;58(15):2477-2495. doi: 10.1021/acs.accounts.5c00355. Epub 2025 Jul 18.
9
Direct Reductive Transformation of Amides: From Methodology Development to Applications in Total Synthesis.酰胺的直接还原转化：从方法学开发到全合成中的应用
Acc Chem Res. 2025 Jul 3. doi: 10.1021/acs.accounts.5c00366.
10
Short-Term Memory Impairment短期记忆障碍

本文引用的文献

1
Visible-light-mediated site-selective C(sp)-H alkylation of tropones facilitates semi-synthesis of cephafortunoids A and B.可见光介导的卓酚酮的位点选择性C(sp)-H烷基化促进了头孢福菌素A和B的半合成。
Chem Sci. 2025 Apr 10;16(20):8836-8844. doi: 10.1039/d5sc01006c. eCollection 2025 May 21.
2
Theoretical Studies on the Reaction Mechanism for the Cycloaddition of Zwitterionic π-Allenyl Palladium Species: Substrate-Controlled Isomerization.两性离子π-烯丙基钯物种环加成反应机理的理论研究：底物控制的异构化
Molecules. 2024 Dec 30;30(1):103. doi: 10.3390/molecules30010103.
3
Highly Regioselective Dehydrogenative Hydrazination of Tropones.
卓酮的高度区域选择性脱氢肼化反应
J Org Chem. 2024 Dec 6;89(23):17853-17859. doi: 10.1021/acs.joc.4c02358. Epub 2024 Nov 15.
4
Substrate-Controlled [8 + 3] Cycloaddition of Tropsulfimides and Tropones with Zwitterionic Allenyl Palladium Species Derived from Vinylidenecyclopropane-diesters.环丙烯二酯衍生的两性离子烯丙基钯物种介导的托普磺酰亚胺和环庚三烯的底物控制[8 + 3]环加成反应
J Org Chem. 2024 Oct 18;89(20):14831-14850. doi: 10.1021/acs.joc.4c01579. Epub 2024 Oct 4.
5
Photosensitizer-free visible-light-promoted glycosylation enabled by 2-glycosyloxy tropone donors.由2-糖氧基环庚三烯酮供体实现的无光敏剂可见光促进的糖基化反应。
Nat Commun. 2023 Dec 4;14(1):8025. doi: 10.1038/s41467-023-43786-y.
6
Quantum Chemical Study of the Cycloaddition Reaction of Tropone with 1,1-Diethoxyethene Catalyzed by B(CF) or BPh.由B(CF)或BPh催化的托酚酮与1,1 - 二乙氧基乙烯环加成反应的量子化学研究
ACS Omega. 2023 Aug 8;8(33):30410-30420. doi: 10.1021/acsomega.3c03560. eCollection 2023 Aug 22.
7
Tropolones and Thailandepsin B as Lead-like Natural Compounds in the Development of Potent and Selective Histone Deacetylase Inhibitors.三并苯酮类和泰国脯氨酸 B 作为潜在的类似物天然化合物在强效和选择性组蛋白去乙酰化酶抑制剂的开发中的应用。
Curr Drug Targets. 2023;24(9):698-717. doi: 10.2174/1389450124666230707144251.
8
Preparation and Synthetic Applications of Phototropone.光蝶呤的制备及合成应用。
J Org Chem. 2023 Jul 7;88(13):9514-9517. doi: 10.1021/acs.joc.3c00590. Epub 2023 Jun 21.
9
Enantioselective (8+3) Cycloadditions by Activation of Donor-Acceptor Cyclopropanes Employing Chiral Brønsted Base Catalysis.利用手性布朗斯特碱催化通过供体-受体环丙烷的活化实现对映选择性(8+3)环加成反应。
Angew Chem Int Ed Engl. 2022 Jul 18;61(29):e202206096. doi: 10.1002/anie.202206096. Epub 2022 May 31.
10
Total Synthesis of Gukulenin B via Sequential Tropolone Functionalizations.通过连续的色酮官能化反应全合成苦马豆素 B
J Am Chem Soc. 2022 Mar 23;144(11):5190-5196. doi: 10.1021/jacs.2c01305. Epub 2022 Mar 11.