Babawale Florence, Ghosh Indrajit, König Burkhard
Fakultät für Chemie und Pharmazie, Universität Regensburg, Regensburg 93040, Germany.
J Org Chem. 2025 Oct 3;90(39):13885-13890. doi: 10.1021/acs.joc.5c01749. Epub 2025 Sep 22.
Indanones are key structural motifs in pharmaceuticals and bioactive natural products, making their efficient synthesis a subject of continued interest. Conventional methods typically rely on transition-metal catalysis, prefunctionalized substrates, and multiple redox steps. Herein, we report a photochemical C-H annulation strategy for the direct synthesis of indanones from simple, unmodified aromatic aldehydes and terminal alkynes. The reaction proceeds under 365 nm light using tetrabutylphosphonium decatungstate ([BuP]WO, TBPDT) as a hydrogen atom transfer (HAT) photocatalyst. This prefunctionalization-free protocol tolerates a broad range of substrates, eliminates the need for additional redox steps, and expands the toolbox for sustainable indanone synthesis.
茚满酮是药物和生物活性天然产物中的关键结构基序，因此其高效合成一直是人们持续关注的课题。传统方法通常依赖于过渡金属催化、预官能化底物和多个氧化还原步骤。在此，我们报道了一种光化学C-H环化策略，用于从简单的、未修饰的芳香醛和末端炔烃直接合成茚满酮。该反应在365 nm光下进行，使用四丁基鏻十钨酸盐（[BuP]WO，TBPDT）作为氢原子转移（HAT）光催化剂。这种无需预官能化的方法能耐受多种底物，无需额外的氧化还原步骤，并扩展了可持续合成茚满酮的方法库。
