Nunez-Rodriguez Eduardo, Mishima Ricardo, Martinez Fiorela, Aveni-Strafile Paloma, Zheng Gang, Hicklen Rachel S, Tsai Edward, Cata Juan
Department of Anesthesiology and Perioperative Medicine, MD Anderson Cancer Center, Houston, Texas, USA.
Anesthesiology and Surgical Oncology Research Group, Houston, Texas, USA.
BMJ Open. 2025 Sep 22;15(9):e104016. doi: 10.1136/bmjopen-2025-104016.
Postoperative arrhythmias are common and clinically significant complications. They are a cause of increased morbidity and mortality rates in surgical patients. Although various pharmacological and procedural strategies have been explored for preventing postoperative arrhythmia, evidence regarding their effectiveness remains inconsistent. The stellate ganglion block (SGB) has emerged as a promising alternative to reduce the occurrence of postoperative arrhythmias. By summarising the existing evidence, this meta-analysis aims to assess the effectiveness of SGB in preventing postoperative arrhythmias.
We will review literature from January 1970 to April 2025 using MEDLINE, Cochrane CENTRAL and Embase. Studies eligible for inclusion will be randomised controlled trials and observational studies reporting postoperative arrhythmia incidence in surgical patients who received preoperative or intraoperative SGB. We will include articles in the following languages: English, Spanish, Chinese or Portuguese. Secondary outcomes are SGB-related complications. The risk of bias will be determined by Rob-2 and ROBINS-I tools. Meta-analyses, reporting relative risks or ORs with 95% confidence intervals will be performed when at least three studies report the same outcome under comparable conditions. Quality of evidence will be evaluated using GRADE guidelines.
We will use information from previously published manuscripts found in reputable databases, and ethical approval is not necessary.
CRD420251029643.
术后心律失常是常见且具有临床意义的并发症。它们是外科手术患者发病率和死亡率增加的一个原因。尽管已经探索了各种药物和程序策略来预防术后心律失常，但其有效性的证据仍不一致。星状神经节阻滞（SGB）已成为减少术后心律失常发生的一种有前景的替代方法。通过总结现有证据，本荟萃分析旨在评估SGB预防术后心律失常的有效性。
我们将使用MEDLINE、Cochrane CENTRAL和Embase检索1970年1月至2025年4月的文献。符合纳入标准的研究将是随机对照试验和观察性研究，报告接受术前或术中SGB的外科手术患者的术后心律失常发生率。我们将纳入以下语言的文章：英语、西班牙语、中文或葡萄牙语。次要结局是与SGB相关的并发症。偏倚风险将通过Rob-2和ROBINS-I工具确定。当至少三项研究在可比条件下报告相同结局时，将进行荟萃分析，报告相对风险或OR值及95%置信区间。证据质量将使用GRADE指南进行评估。
我们将使用在知名数据库中找到的先前发表的手稿中的信息，无需伦理批准。
PROSPERO注册号：CRD420251029643。
