Zhang Yan, Chu Meiling, Ye Meina, Yin Yulian, Chen Hongfeng
Department of Breast Surgery, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 725 South Wanping Road, Shanghai, 200032, China.
Department of General Surgery, Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, 200137, China.
Biol Proced Online. 2025 Sep 22;27(1):36. doi: 10.1186/s12575-025-00296-z.
Suppressor of Cytokine Signaling 3 (SOCS3) is a critical regulator of cytokine signaling, primarily acting through the Janus Kinase (JAK)/Signal Transducer and Activator of Transcription (STAT) pathway. It plays a significant role in the development and progression of various malignancies. Abnormal expression of SOCS3 in cancer cells is linked to dysregulated cell growth, migration, and apoptosis, driven by cytokines and hormones. This aberrant expression makes SOCS3 a potential biomarker for tumor diagnosis, prognosis, and gene therapy. Targeting SOCS3 may offer innovative strategies for cancer treatment. This review provides a comprehensive overview of SOCS3's molecular structure, its biological functions in tumors, underlying molecular mechanisms, and therapeutic strategies targeting SOCS3.
细胞因子信号转导抑制因子3（SOCS3）是细胞因子信号传导的关键调节因子，主要通过Janus激酶（JAK）/信号转导子和转录激活子（STAT）途径发挥作用。它在各种恶性肿瘤的发生和发展中起着重要作用。癌细胞中SOCS3的异常表达与细胞因子和激素驱动的细胞生长、迁移和凋亡失调有关。这种异常表达使SOCS3成为肿瘤诊断、预后和基因治疗的潜在生物标志物。靶向SOCS3可能为癌症治疗提供创新策略。本综述全面概述了SOCS3的分子结构、其在肿瘤中的生物学功能、潜在分子机制以及靶向SOCS3的治疗策略。
