聚对甲苯磺酸钠的抗补体、抗凝和血清蛋白沉淀活性。
Anticomplementary, anticoagulatory, and serum-protein precipitating activity of sodium polyanetholsulfonate.
作者信息
Traub W H, Lowrance B L
出版信息
Appl Microbiol. 1970 Sep;20(3):465-8. doi: 10.1128/am.20.3.465-468.1970.
Abstract
Sodium polyanetholsulfonate (SPS) at 7.8 mug/ml completely abolished complement-mediated hemolysis of 1:10 diluted fresh guinea pig and human serum; at least twice as much SPS was required to reduce complement activity in 1:2 diluted human serum. The coagulation of 90 and 20% human blood was inhibited by 250 and 125 mug of SPS per ml, respectively. When added to fresh human serum, SPS precipitated beta 1C-globulin (C3), C4, beta lipoproteins, immunoglobulin IgG, IgM, and IgA, though incompletely.
摘要
每毫升含7.8微克的聚茴香脑磺酸钠（SPS）能完全消除1:10稀释的新鲜豚鼠血清和人血清中补体介导的溶血现象；而要降低1:2稀释的人血清中的补体活性，所需的SPS量至少是前者的两倍。每毫升250微克和125微克的SPS分别抑制了90%和20%人血的凝固。当添加到新鲜人血清中时，SPS能沉淀β1C球蛋白（C3）、C4、β脂蛋白、免疫球蛋白IgG、IgM和IgA，不过沉淀不完全。
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