Biju Bennett Kurien, Andavar Marina
Department of Pharmacy Practice, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, Chengalpattu, Tamil Nadu, 603 203, India.
Inflammopharmacology. 2025 Sep 23. doi: 10.1007/s10787-025-01947-z.
Resveratrol, a polyphenolic compound predominantly found in grapes and red wine, exhibits significant biological activity due to its potent antioxidant and anti-inflammatory properties. Known for its cardioprotective, chemotherapeutic, neuroprotective, and anti-aging effects, resveratrol has garnered attention for its potential in managing age-related ocular diseases, such as glaucoma, cataract, diabetic retinopathy, and macular degeneration-conditions, where oxidative stress and inflammation play central roles in disease progression and vision impairment. Both in vitro and animal studies indicate that resveratrol impacts key biological pathways, including oxidative stress modulation, inflammation reduction, mitochondrial protection, apoptosis regulation, and angiogenesis suppression, which are implicated in the pathology of these ocular conditions. Resveratrol with antioxidant, anti-inflammatory, and anti-angiogenic properties, shows promise in treating ophthalmic diseases by targeting oxidative stress and abnormal angiogenesis, offering a safer, non-invasive alternative to conventional drugs and better scientific validation than herbal remedies. This review synthesizes current research on resveratrol's mechanisms of action, therapeutic potential, and limitations as a treatment for eye disorders, highlighting its promise as a nutritional intervention and areas requiring further exploration.
白藜芦醇是一种主要存在于葡萄和红酒中的多酚类化合物，因其强大的抗氧化和抗炎特性而具有显著的生物活性。白藜芦醇以其对心脏的保护作用、化疗作用、神经保护作用和抗衰老作用而闻名，它在治疗与年龄相关的眼部疾病方面的潜力已引起关注，如青光眼、白内障、糖尿病视网膜病变和黄斑变性等病症，在这些病症中氧化应激和炎症在疾病进展和视力损害中起核心作用。体外研究和动物研究均表明，白藜芦醇会影响关键的生物途径，包括氧化应激调节、炎症减轻、线粒体保护、细胞凋亡调控和血管生成抑制，这些途径与这些眼部疾病的病理过程有关。具有抗氧化、抗炎和抗血管生成特性的白藜芦醇，通过针对氧化应激和异常血管生成，在治疗眼科疾病方面显示出前景，为传统药物提供了一种更安全、非侵入性的替代方案，并且比草药疗法有更好的科学验证。这篇综述综合了目前关于白藜芦醇作为眼部疾病治疗方法的作用机制、治疗潜力和局限性的研究，强调了其作为营养干预手段的前景以及需要进一步探索的领域。
