Chen Si-Yu, Wang Li, Yang Jian-Wei, Wang Kang-Yu, Li Xiao-Ran, Yang Li
Department of Urology, Gansu Province Clinical Research Center for Urinary System Disease, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, China.
Institute of Urology, Gansu Province Clinical Research Center for Urinary System Disease, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, China.
Medicine (Baltimore). 2025 Sep 19;104(38):e44653. doi: 10.1097/MD.0000000000044653.
This study explored the relationship between the alternative Mediterranean Diet (aMED) score and the prevalence of kidney stones (KSD) among adults in US. This cross-sectional analysis utilized data from the National Health and Nutrition Examination Survey spanning 2007 to 2018. The study population comprised adults aged 20 years and older who provided comprehensive dietary recall information and detailed histories of KSD. Adherence to the Mediterranean diet was quantified using the aMED score, which was divided into 4 quartiles for comparison. To evaluate the association between aMED scores and KSD prevalence, we employed weighted multivariable logistic regression, conducted restricted cubic spline analyses, and performed subgroup investigations. Of the 28,059 participants, 10.08% reported a history of KSD. The weighted mean age (95% CI) was 47.97 years (47.49, 48.45). Males comprised 52.49% (50.08%, 54.90%) of the sample, while females made up 47.51% (45.32%, 49.70%). The restricted cubic spline analysis revealed a negative linear association between the aMED score and the likelihood of KSD development. In a fully adjusted model, individuals in the highest quartile of aMED scores (Q4) were found to have a significantly lower risk of KSD compared to those in the lowest quartile (Q1), with an odds ratio of 0.771 (95% CI: 0.616-0.966, P = .024). An increased aMED score was associated with a lower prevalence of KSD in U.S. adults. This cross-sectional study provides observational evidence suggesting a potential link between dietary patterns and KSD prevalence, which may inform future dietary intervention research.
本研究探讨了替代地中海饮食（aMED）评分与美国成年人肾结石（KSD）患病率之间的关系。这项横断面分析利用了2007年至2018年的国家健康与营养检查调查数据。研究人群包括20岁及以上提供全面饮食回忆信息和KSD详细病史的成年人。使用aMED评分对地中海饮食的依从性进行量化，该评分分为4个四分位数进行比较。为了评估aMED评分与KSD患病率之间的关联，我们采用了加权多变量逻辑回归，进行了受限立方样条分析，并进行了亚组调查。在28059名参与者中，10.08%报告有KSD病史。加权平均年龄（95%CI）为47.97岁（47.49，48.45）。男性占样本的52.49%（50.08%，54.90%），女性占47.51%（45.32%，49.70%）。受限立方样条分析显示aMED评分与KSD发生可能性之间存在负线性关联。在完全调整模型中，发现aMED评分最高四分位数（Q4）的个体与最低四分位数（Q1）的个体相比，KSD风险显著降低，优势比为0.771（95%CI：0.616 - 0.966，P = 0.024）。aMED评分升高与美国成年人KSD患病率降低相关。这项横断面研究提供了观察性证据，表明饮食模式与KSD患病率之间可能存在联系，这可能为未来的饮食干预研究提供参考。
