Gallée Jeanne, Gibbons Laura E, Choi Seo-Eun, Lee Michael, Scollard Phoebe, Trittschuh Emily H, Mez Jesse, Saykin Andrew J, Foldi Nancy S, Mukherjee Shubhabrata, Crane Paul K
Center for Psychometric Analyses of Aging and Neurodegeneration, Department of Medicine, University of Washington, Seattle, Washington, USA.
Alzheimer's Disease Research Center, University of Washington, Seattle, Washington, USA.
Alzheimers Dement. 2025 Sep;21(9):e70705. doi: 10.1002/alz.70705.
Early-onset Alzheimer's disease dementia (EOAD) is characterized by more pronounced cognitive decline than late-onset AD dementia (LOAD). Characteristic performance in spoken language remains undefined.
A cross-sectional analysis of 1189 people with EOAD and 4646 with LOAD from the National Alzheimer's Coordinating Center (NACC) was conducted.
Based on data from their first NACC visit with AD, there was considerable heterogeneity in language performance across people with EOAD and LOAD. The distribution of naming ability was similar across these groups. On average, people with LOAD performed better than those with EOAD in category fluency, letter fluency, and spoken lexical retrieval, and had lower Clinical Dementia Rating (CDR) Language scores, although there was considerable overlap in the distributions for participants with EOAD and those with LOAD.
At diagnosis, the language profiles of EOAD and LOAD are distinct. There is substantial variability in both groups in multiple aspects of language.
Early-onset Alzheimer's disease (EOAD) is associated with significantly poorer category and phonemic fluency and global spoken lexical retrieval compared to late-onset Alzheimer's disease (LOAD) at time of diagnosis. Participants with EOAD dementia show greater severity and variability in clinician-rated language functioning, as measured by Clinical Dementia Rating (CDR) Language scores. No significant group differences were observed in confrontation naming performance between EOAD and LOAD dementia. Findings support that there are distinct profiles of language performance in EOAD and LOAD at time of dementia diagnosis.
早发性阿尔茨海默病性痴呆（EOAD）的特征是认知衰退比晚发性阿尔茨海默病性痴呆（LOAD）更为明显。口语方面的特征表现仍不明确。
对来自国家阿尔茨海默病协调中心（NACC）的1189例早发性阿尔茨海默病患者和4646例晚发性阿尔茨海默病患者进行了横断面分析。
根据他们首次到NACC进行阿尔茨海默病评估的数据，早发性阿尔茨海默病患者和晚发性阿尔茨海默病患者的语言表现存在相当大的异质性。这些组之间的命名能力分布相似。平均而言，在类别流畅性、字母流畅性和口语词汇检索方面，晚发性阿尔茨海默病患者的表现优于早发性阿尔茨海默病患者，且临床痴呆评定量表（CDR）语言得分更低，尽管早发性阿尔茨海默病患者和晚发性阿尔茨海默病患者的分布有相当大的重叠。
在诊断时，早发性阿尔茨海默病和晚发性阿尔茨海默病的语言特征是不同的。两组在语言的多个方面都存在很大的变异性。
与诊断时的晚发性阿尔茨海默病（LOAD）相比，早发性阿尔茨海默病（EOAD）与明显更差的类别和音素流畅性以及整体口语词汇检索相关。早发性阿尔茨海默病性痴呆患者在临床痴呆评定量表（CDR）语言得分所衡量的临床医生评定的语言功能方面表现出更大的严重程度和变异性。在早发性阿尔茨海默病性痴呆和晚发性阿尔茨海默病性痴呆之间，在对名表现方面未观察到显著的组间差异。研究结果支持在痴呆诊断时，早发性阿尔茨海默病和晚发性阿尔茨海默病存在不同的语言表现特征。
