Liu Weijie, Rao Wei, Zhu JunYe, Hu Xiaozhou, Tu Yunhai, Wu Wencan, Ye Jie
National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, 270 Xueyuan Road, Wenzhou, 325027, Zhejiang, China.
J Transl Med. 2025 Sep 24;23(1):1014. doi: 10.1186/s12967-025-07043-8.
To measure alterations in quadrant asymmetry (QA) of retinal radial peripapillary capillary (RPC) density and to determine the association between subfield alterations and thyroid-associated ophthalmopathy (TAO).
Optical coherence tomography angiography images of 51 control eyes and 80 TAO eyes were analyzed to quantify RPC density. QA was defined as the difference between the maximum and minimum RPC densities among four subfields. Comparisons of RPC QA between groups and the associations of QA with the occurrence of TAO were analyzed. Linear regression was conducted to determine the association of subfield alterations with visual field mean deviation (MD).
QA of RPC density in TAO eyes was higher than in control eyes (9.58 ± 2.40 vs. 6.70 ± 2.01, P < 0.001), although no significant difference was observed in global RPC density between the TAO and control groups (P = 0.395). QA of RPC density demonstrated a high area under the curve (AUC = 0.816) for detecting TAO, whereas the AUC of global RPC density was only 0.564. Among the four subfields, only nasal RPC density showed a significant decrease in TAO eyes (48.03 ± 2.56 vs. 50.19 ± 2.79, P < 0.001). Univariate linear regression revealed that nasal RPC density was correlated with visual field MD (standardized coefficient = 0.243, P = 0.005), whereas RPC density in the other three subfields did not show significant correlations (all P ≥ 0.082).
Alterations in quadrant asymmetry of RPC density occurred in TAO, particularly decreased RPC density in the nasal subfield, which was significantly associated with visual field abnormalities in TAO.
测量视网膜放射状视乳头周围毛细血管（RPC）密度象限不对称性（QA）的变化，并确定亚区域改变与甲状腺相关眼病（TAO）之间的关联。
分析51只对照眼和80只TAO眼的光学相干断层扫描血管造影图像，以量化RPC密度。QA定义为四个亚区域中最大和最小RPC密度之间的差异。分析了组间RPC QA的比较以及QA与TAO发生的关联。进行线性回归以确定亚区域改变与视野平均偏差（MD）的关联。
TAO眼RPC密度的QA高于对照眼（9.58±2.40对6.70±2.01，P<0.001），尽管TAO组和对照组之间的整体RPC密度无显著差异（P=0.395）。RPC密度的QA在检测TAO方面显示出较高的曲线下面积（AUC=0.816），而整体RPC密度的AUC仅为0.564。在四个亚区域中，只有鼻侧RPC密度在TAO眼中显著降低（48.03±2.56对50.19±2.79，P<0.001）。单变量线性回归显示鼻侧RPC密度与视野MD相关（标准化系数=0.243，P=0.005），而其他三个亚区域的RPC密度未显示出显著相关性（所有P≥0.082）。
TAO中发生了RPC密度象限不对称性的改变，特别是鼻侧亚区域的RPC密度降低，这与TAO中的视野异常显著相关。
