亚急性硬化性全脑炎中的麻疹免疫球蛋白
Measles immunoglobulins in subacute sclerosing panencephalitis.
作者信息
Connolly J H, Haire M, Hadden D S
出版信息
Br Med J. 1971 Jan 2;1(5739):23-5. doi: 10.1136/bmj.1.5739.23.
Abstract
Normal responses of measles specific immunoglobulins M and G (IgM and IgG) were defined in 10 children with measles. Abnormal responses of measles IgM and IgG were found in both sera and cerebrospinal fluids from three cases of subacute sclerosing panencephalitis. In two patients the serum titres of measles IgM and IgG were abnormally high. The measles IgM was present during prolonged illnesses in serum and cerebrospinal fluid, which suggested a correlation with the known persistence of measles virus antigen in the brain of the three patients. It was concluded that both measles IgM and IgG may be produced within the central nervous system in subacute sclerosing panencephalitis.
摘要
在10名患麻疹的儿童中确定了麻疹特异性免疫球蛋白M和G（IgM和IgG）的正常反应。在3例亚急性硬化性全脑炎患者的血清和脑脊液中均发现麻疹IgM和IgG反应异常。2例患者的麻疹IgM和IgG血清滴度异常高。在病程延长期间，血清和脑脊液中均存在麻疹IgM，这表明与3例患者大脑中已知的麻疹病毒抗原持续存在相关。得出的结论是，在亚急性硬化性全脑炎中，中枢神经系统内可能会产生麻疹IgM和IgG。
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