Vandvik B, Norrby E, Nordal H J, Degré M
Scand J Immunol. 1976;5(8):979-92. doi: 10.1111/j.1365-3083.1976.tb03050.x.
Measles virus-specific antibodies were isolated from sera, cerebrospinal fluids (CSF), and brain extracts of patients with subacute sclerosing panencephalitis (SSPE) and multiple sclerosis (MS) by absorption with measles antigens and subsequent acid elution of the antigen-antibody precipitates. Electrophoretically homogeneous measles antibodies were isolated from CSF or brain extracts in five patients with SSPE and in five out of seven patients with MS. Homogeneous IgG antibodies were also demonstrated in the sera from all SSPE patients and from three of the MS patients. The antibodies isolated from various control sera and from pooled CSF were electrophoretically heterogeneous. The results support the concept of a local synthesis in the nervous system of oligoclonal IgG antibodies to measles virus in all patients with SSPE and in some patients with MS. In SSPE, most or all oligoclonal IgG proteins of the CSF or brain carry measles antibody activities. In MS, only part of the oligoclonal IgG appears to be associated with measles antibody activity.
通过用麻疹抗原吸附，随后对抗原 - 抗体沉淀物进行酸洗脱，从患有亚急性硬化性全脑炎（SSPE）和多发性硬化症（MS）患者的血清、脑脊液（CSF）及脑提取物中分离出麻疹病毒特异性抗体。从5例SSPE患者以及7例MS患者中的5例的脑脊液或脑提取物中分离出电泳均一的麻疹抗体。在所有SSPE患者和3例MS患者的血清中也证实有均一的IgG抗体。从各种对照血清和汇集的脑脊液中分离出的抗体在电泳上是异质的。这些结果支持了在所有SSPE患者和一些MS患者的神经系统中局部合成针对麻疹病毒的寡克隆IgG抗体这一概念。在SSPE中，脑脊液或脑中的大多数或所有寡克隆IgG蛋白都具有麻疹抗体活性。在MS中，只有部分寡克隆IgG似乎与麻疹抗体活性有关。
