Lee Sang Hoon, Kim Eun Bae, Park Sung Chul, Nam Seung-Joo, Cho Hyunseok, Jeon Han Jo, Lee Sang Pyo
Department of Internal Medicine, Kangwon National University College of Medicine, Chuncheon, Republic of Korea.
Department of Applied Animal Science, Kangwon National University College of Animal Life Sciences, Chuncheon, Republic of Korea.
Front Cell Infect Microbiol. 2025 Sep 9;15:1651316. doi: 10.3389/fcimb.2025.1651316. eCollection 2025.
Obesity is a multifactorial condition influenced by various factors, including the gut microbiota. However, the relationship between the gastric microbiota and obesity remains poorly understood. This study aimed to investigate the composition of gastric microbiota, excluding , in relation to body mass index (BMI) and metabolic indicators.
Thirty participants undergoing health checkups were classified into three groups-normal weight (BMI 18.5-22.9), overweight (BMI 23.0-24.9), and obese (BMI ≥25.0)-with ten individuals per group. Those with infection, atrophic gastritis, or intestinal metaplasia were excluded. Gastric microbiota from four antral biopsies per subject were analyzed using 16S rRNA sequencing and functional profiling by metagenomic prediction.
Alpha diversity (Gini-Simpson index) was significantly lower in the combined overweight/obese group than that in the normal group (=0.049). Beta diversity analysis revealed clear group separation (Bray-Curtis, =0.005; unweighted UniFrac, =0.004). Significant species differences between the groups were observed; specifically, the abundances of , , and , were significantly reduced in the overweight/obese group. Functional predictions showed differential enrichment of pathways related to fatty acid, amino acid, vitamin, and carbohydrate metabolism across BMI categories. These findings suggest that alterations in the gastric microbiota may be linked to obesity and metabolic dysregulation.
肥胖是一种受多种因素影响的多因素疾病，包括肠道微生物群。然而，胃微生物群与肥胖之间的关系仍知之甚少。本研究旨在调查胃微生物群的组成，不包括 ，与体重指数（BMI）和代谢指标的关系。
30名接受健康检查的参与者被分为三组——正常体重（BMI 18.5 - 22.9）、超重（BMI 23.0 - 24.9）和肥胖（BMI≥25.0）——每组10人。排除有 感染、萎缩性胃炎或肠化生的个体。使用16S rRNA测序和宏基因组预测的功能分析对每个受试者的四个胃窦活检样本中的胃微生物群进行分析。
超重/肥胖合并组的α多样性（基尼-辛普森指数）显著低于正常组（=0.049）。β多样性分析显示各组之间有明显的分离（布雷-柯蒂斯距离，=0.005；非加权UniFrac距离，=0.004）。观察到各组之间存在显著的物种差异；具体而言，超重/肥胖组中 、 和 的丰度显著降低。功能预测表明，跨BMI类别，与脂肪酸、氨基酸、维生素和碳水化合物代谢相关的途径存在差异富集。这些发现表明，胃微生物群的改变可能与肥胖和代谢失调有关。
