Rajan Ahana S, Tanaka Eiji
Department of Orthodontics, Meenakshi Ammal Dental College and Hospital, Meenakshi Academy of Higher Education and Research (Deemed to be University), Chennai 600095, Tamil Nadu, India.
Department of Orthodontics and Dentofacial Orthopedics, Tokushima University Graduate School of Biomedical Sciences, Tokushima 770-8503, Japan.
Dent J (Basel). 2025 Aug 31;13(9):400. doi: 10.3390/dj13090400.
The craniofacial region is functionally unique, with close interaction between muscles and bones during mastication, speech, and facial expression. Although myokines, muscle-derived signaling molecules, are increasingly being studied in relation to bone metabolism, most studies have focused on limb muscles and long bones. Given the developmental and functional specificity of craniofacial structures, this article aims to map the current evidence on myokines involved in craniofacial bone metabolism and to identify gaps in order to guide future research. : We conducted a literature search in PubMed and Scopus (January 2000-July 2025), combining both free-text keywords and MeSH terms to ensure comprehensive retrieval of relevant articles. Nine articles from the extensive search were included in this review that adhered to the eligibility criteria. The myokines that were reported include interleukin-6, insulin like growth factor-1, and myostatin and irisin. Further research is required into the mechanism by which craniofacial muscle-derived myokines regulate local bone metabolism, as this knowledge could pave the way for novel therapeutic strategies that leverage myokine signaling, which could be applied in the context of orthodontic and orthognathic treatments, maxillofacial reconstruction, or age-related bone loss.
颅面部区域功能独特，在咀嚼、言语和面部表情过程中肌肉与骨骼之间存在密切相互作用。尽管肌动蛋白，即肌肉衍生的信号分子，在骨代谢方面的研究越来越多，但大多数研究都集中在肢体肌肉和长骨上。鉴于颅面部结构的发育和功能特异性，本文旨在梳理有关参与颅面部骨代谢的肌动蛋白的现有证据，并找出差距以指导未来研究。我们在PubMed和Scopus数据库（2000年1月至2025年7月）中进行了文献检索，结合自由文本关键词和医学主题词以确保全面检索相关文章。此次广泛检索得到的9篇文章符合纳入标准，被纳入本综述。所报道的肌动蛋白包括白细胞介素-6、胰岛素样生长因子-1、肌肉生长抑制素和鸢尾素。需要进一步研究颅面部肌肉衍生的肌动蛋白调节局部骨代谢的机制，因为这一知识可为利用肌动蛋白信号的新型治疗策略铺平道路，这些策略可应用于正畸和正颌治疗、颌面重建或与年龄相关的骨质流失情况。
