Kim Jihyun, Jung Yoona, Lee Yong-Seok, Choi Seong-Won, Hwang Geelsu, Yun Kwidug
Department of Prosthodontics, School of Dentistry, Chonnam National University, Gwangju 61186, Republic of Korea.
Department of Mechanical Engineering, Konkuk University, Seoul 05029, Republic of Korea.
Biomimetics (Basel). 2025 Sep 3;10(9):583. doi: 10.3390/biomimetics10090583.
The surface treatments and various magnesium alloys are applied to improve the fast degradation rate and resulting negative effects of magnesium alloys. This study aimed to assess the effect of anodic oxidation treatment of magnesium-calcium (Mg-Ca) systems by creating artificial bone defects in the tibia of rats. The cylinder magnesium implants were fabricated using a Mg-xCa (x = 0, 1, 5 wt.%) binary alloy. Degradability and new bone formation were observed at two and six weeks using micro-CT. Histomorphometric parameters were evaluated with Goldner's trichrome staining. The degradation rate decreased depending on the amount of calcium added. The parameters related to bone formation revealed an increasing pattern depending on the addition of calcium, anodic oxidation, and time. The amount of absorbed magnesium to assess degradability of magnesium implants by the histomorphometric analysis revealed a high value in the untreated group at two and six weeks. Bone healing parameters increased depending on the amount of calcium added, anodic oxidation treatment, and region of interest (ROI-0.5 mm, 1.00 mm, 1.5 mm, and 2.0 mm). Biodegradable magnesium systems have the potential to replace bone screws and plates. Combination with calcium combined with anodization surface treatment can improve initial corrosion resistance and promote bone formation.
应用表面处理和各种镁合金来改善镁合金快速降解率及其产生的负面影响。本研究旨在通过在大鼠胫骨中制造人工骨缺损来评估镁钙（Mg-Ca）系统阳极氧化处理的效果。使用Mg-xCa（x = 0、1、5 wt.%）二元合金制造圆柱形镁植入物。在两周和六周时使用微型计算机断层扫描（micro-CT）观察降解性和新骨形成情况。用戈德纳三色染色法评估组织形态计量学参数。降解率随钙添加量的增加而降低。与骨形成相关的参数随钙添加量、阳极氧化处理和时间的增加呈上升趋势。通过组织形态计量学分析评估镁植入物降解性的镁吸收量在未处理组的两周和六周时显示出较高值。骨愈合参数随钙添加量、阳极氧化处理和感兴趣区域（ROI - 0.5毫米、1.00毫米、1.5毫米和2.0毫米）的增加而增加。可生物降解镁系统有潜力替代骨螺钉和骨板。钙与阳极氧化表面处理相结合可提高初始耐腐蚀性并促进骨形成。
