Adou Ahissan Innocent, Fleurima Ebed, Thesnor Valendy, Urrutia Ander, Fournet Alain, Sylvestre Marie-Noëlle, Sylvestre Muriel, Benfodda Zohra, Cebrián-Torrejón Gerardo
Laboratoire COVACHIM-M2E, Faculté des Sciences Exactes et Naturelles, Université des Antilles, 97159 Pointe-à-Pitre, France.
Institut de Systématique, Evolution, Biodiversité (ISYEB), Muséum National d'Histoire Naturelle, CNRS, Faculté des Sciences Exactes et Naturelles, B.P. 592, 97159 Pointe-à-Pitre, France.
Metabolites. 2025 Sep 16;15(9):614. doi: 10.3390/metabo15090614.
Lam. is a member of the Rutaceae Family that can be naturally found in South and central America (Brazil, Paraguay, Bolivia, Caribbean, etc.). Its traditional medicinal uses are well documented among native communities, such as that of the Guarani, in Paraguay. More than 60 metabolites, including alkaloids, terpenoids, coumarins, and alkylamides, have been identified in its leaves, bark, and fruits. The biological activities and mechanisms of action of several of these compounds, as well as those of crude extracts, have also been investigated by previous studies. As a medicinal and edible plant, shows promising applications in the pharmacological industry. For the last 25 years, a significant amount of research has been conducted with to better understand its toxicity and complex mechanisms of action, bringing science-based clinical safety to its traditional uses. This review integrates available knowledge chemical and biological data on this species. It emphasizes the diversity of bioactive metabolites, their associated bioactivities, and provides an updated overview of the plant's advances in ethnopharmacology, phytochemistry, pharmacology, agricultural exploitation, and potential utilization.
拉米（Lam.）是芸香科的一员，在南美洲和中美洲（巴西、巴拉圭、玻利维亚、加勒比地区等）可自然生长。其传统药用价值在当地社区，如巴拉圭的瓜拉尼族中，有详尽记载。在其叶子、树皮和果实中已鉴定出60多种代谢物，包括生物碱、萜类化合物、香豆素和烷基酰胺。先前的研究还对其中几种化合物以及粗提取物的生物活性和作用机制进行了研究。作为一种药用和食用植物，它在制药行业显示出广阔的应用前景。在过去25年里，人们对拉米进行了大量研究，以更好地了解其毒性和复杂的作用机制，为其传统用途带来基于科学的临床安全性。本综述整合了关于该物种的现有化学和生物学知识数据。它强调了生物活性代谢物的多样性及其相关生物活性，并提供了该植物在民族药理学、植物化学、药理学、农业开发和潜在利用方面进展的最新概述。
