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氧化锌纳米颗粒对鸡胚基因组和氧化还原状态的影响——形状的作用

Zinc Oxide Nanoparticles Affect the Genomic and Redox Status of Chicken Embryo-Influence of Shape.

作者信息

Dominiak Bartłomiej, Rosowska Julita, Wal Agnieszka, Majewska Alicja, Witkowski Bartłomiej S, Wachnicki Łukasz, Kaszewski Jarosław, Słońska Anna, Cymerys Joanna, Gralak Mikołaj A, Godlewski Marek, Godlewski Michał M

机构信息

Department of Physiological Sciences, Institute of Veterinary Medicine, Warsaw University of Life Sciences-SGGW, Nowoursynowska 159, 02-776 Warsaw, Poland.

Institute of Physics PAS, Polish Academy of Sciences, Al. Lotników 32/46, 02-668 Warsaw, Poland.

出版信息

Nanomaterials (Basel). 2025 Sep 13;15(18):1412. doi: 10.3390/nano15181412.

DOI:10.3390/nano15181412
PMID:41003048
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12472910/
Abstract

With the spread of nanotechnology use in industry, exposure to nanomaterials is currently exponentially increasing. With reports indicating nanoparticles' ability to pass through key biological barriers-gastrointestinal, lung, skin, blood-brain and the placenta barriers-the question of their safety, particularly the risks associated with embryonic development, arises. The aim of this article is to verify the impact of ZnO nanoparticles, which are commonly used and considered to be safe for adult organisms on the developing embryo. In the current study, the influence of the dose and shape of ZnO nanoparticles (oval vs. long) was evaluated in the chicken embryo model. The oxidative stress (superoxide dismutase (SOD)) activity, malondialdehyde (MDA) and carbonylated protein ((CP) levels), and gene expression changes (full genomic microarray study) were tested. We found that at both doses (10 µg/mL and 100 µg/mL, 100 µL into the air chamber) neither elongated nor oval ZnO nanoparticles changed in ovo mortality. Long ZnO nanoparticles had a lesser and more delayed impact on evaluated parameters, regardless of their higher in vitro toxicity. However, both nanoparticle forms induced changes in the oxidoreductive potential and affected expression of a significant number (1487 for oval and 548 for long ZnO nanoparticles) of identified genes during early embryo development.

摘要

随着纳米技术在工业中的应用不断普及，目前人们接触纳米材料的机会正呈指数级增长。有报告指出纳米颗粒能够穿过关键的生物屏障——胃肠道、肺部、皮肤、血脑屏障以及胎盘屏障，这就引发了关于其安全性的问题，尤其是与胚胎发育相关的风险。本文旨在验证氧化锌纳米颗粒（ZnO纳米颗粒）对发育中胚胎的影响，ZnO纳米颗粒在成人机体中普遍使用且被认为是安全的。在本研究中，我们在鸡胚模型中评估了ZnO纳米颗粒的剂量和形状（椭圆形与长形）的影响。测试了氧化应激（超氧化物歧化酶（SOD））活性、丙二醛（MDA）和羰基化蛋白（（CP）水平）以及基因表达变化（全基因组微阵列研究）。我们发现，在两种剂量下（10μg/mL和100μg/mL，向气室中注入100μL），无论是细长形还是椭圆形的ZnO纳米颗粒都未改变胚胎在卵内的死亡率。尽管长形ZnO纳米颗粒在体外具有更高的毒性，但对所评估参数的影响较小且更为延迟。然而，在胚胎早期发育过程中，两种纳米颗粒形式均诱导了氧化还原电位的变化，并影响了大量（椭圆形ZnO纳米颗粒为1487个，长形ZnO纳米颗粒为548个）已鉴定基因的表达。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4861/12472910/d8a09b5c3f3d/nanomaterials-15-01412-g018.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4861/12472910/d8a09b5c3f3d/nanomaterials-15-01412-g018.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4861/12472910/caa1a9784729/nanomaterials-15-01412-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4861/12472910/a896d7a02e75/nanomaterials-15-01412-g010.jpg
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3
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